What is the main function of Acotiamide?

Acotiamide is an innovative drug developed specifically for functional dyspepsia (FD). It is mainly used to relieve symptoms such as postprandial fullness, upper abdominal bloating, early satiety, and mild nausea. Functional dyspepsia is a common gastrointestinal dysfunction disease. Patients often experience insufficient gastric motility, epigastric discomfort, and a sense of fullness after eating, which seriously affects daily life and diet quality. Acotiamide increases gastrointestinal acetylcholine concentration by selectively inhibiting acetylcholinesterase (AChE), thereby enhancing the contractility of smooth muscle in the gastric antrum and pylorus area, improving gastrointestinal motility, and effectively promoting gastric emptying.

Compared with traditional gastromotility drugs, the advantage of acotiamide is its precise improvement of postprandial symptoms while having a lower incidence of side effects. Clinical studies have shown that acotiamide can improve patients' gastric motility, reduce postprandial fullness and early satiety, and improve patients' dietary tolerance and quality of life. The drug is mainly administered orally and taken three times a day with meals to ensure that the drug takes effect during the post-meal peak period. Its sedative side effects are mild. Common adverse reactions include mild headache, upper abdominal discomfort, occasional dry mouth and mild diarrhea. Serious adverse reactions are rare and the overall tolerance is good.

In multicenter clinical trials, acotiamide was shown to significantly improve patient symptom scores and gastric emptying function. This provides a new option for the drug treatment of functional dyspepsia, especially for patients who cannot tolerate or have ineffective effects of traditional prokinetic drugs. For patients with long-term gastric motility disorders, acotiamide can be used as a continuous management solution to help improve eating experience and quality of life. In summary, acotiamide provides a safe, effective and highly targeted treatment for patients with functional dyspepsia by regulating acetylcholine signaling and enhancing gastrointestinal motility.

Reference: https://www.rad-ar.or.jp/siori/english/search/result?n=33322