Six major dietary and lifestyle taboos that you need to pay attention to when taking Seleniso (Silvio)

Selinexor (trade name: Xivio) is an oral selective nuclear export inhibitor (SINE), mainly used to treat patients with relapsed or refractory multiple myeloma and certain lymphomas. During treatment with selinesol, because the drug may cause adverse reactions such as loss of appetite, nausea, vomiting, fatigue, hematological abnormalities, and metabolic disorders, patients need to pay special attention to diet and lifestyle to ensure drug efficacy and physical health. The following summarizes six dietary and lifestyle taboos for patients’ reference.

1. Avoid high-fat and greasy foods

Seleniso may cause nausea, diarrhea, and indigestion. High-fat or greasy food will increase gastrointestinal burden and reduce drug tolerance. Patients should choose a light and easy-to-digest diet, such as steamed, boiled, and stewed foods, and eat less fried, creamy, and pastry foods. If necessary, the daily meal can be divided into multiple small meals to relieve gastrointestinal discomfort, improve appetite, and help drug absorption.

2. Avoid high-salt and high-sugar diets

A high-salt diet may aggravate water and sodium retention and cause an increase in blood pressure, and some patients may experience cardiovascular and renal function-related adverse reactions during selinesol treatment. A high-sugar diet may aggravate blood sugar fluctuations and affect metabolic balance. Patients should try to reduce processed foods, desserts, and pickled products with high salt content in their daily diet to ensure a balanced intake of protein, carbohydrates, and fats to maintain the body's nutritional needs.

3. Avoid alcohol and irritating drinks

Alcohol can increase the metabolic burden on the liver, and selinesol may cause an increase in liver function indicators. Exciting drinks such as coffee and strong tea may aggravate palpitations, insomnia, or gastrointestinal discomfort, and affect drug absorption and tolerance. During treatment, you should try to avoid drinking alcohol and high-caffeine drinks, and maintain adequate fluid intake. At the same time, you can drink warm water, light tea or clear soup appropriately to help gastrointestinal motility and drug absorption.

4. Avoid excessive dieting or extreme weight loss

One of the common adverse reactions of selinesol is decreased appetite and weight loss. Excessive dieting or the pursuit of rapid weight loss may lead to malnutrition, reduced immunity, and reduced tolerance to treatment. Patients should reasonably consume high-protein and high-calorie foods, such as eggs, lean meat, soy products and whole grains, under the guidance of a doctor or nutritionist to maintain weight and muscle mass and reduce the impact of drug side effects on the body.

5. Avoid raw or unhygienic food

Selinisol may cause hematological abnormalities, such as a decrease in white blood cells, and increase the risk of infection. Raw or unhygienic food can easily carry bacteria or viruses and cause infection. Patients should try to choose cooked foods in their diet, ensure that the ingredients are clean, and avoid sashimi, raw meat, raw eggs, and fruits and vegetables that have not been fully washed. At the same time, pay attention to tableware hygiene to reduce cross-contamination and protect the body with compromised immunity.

6. Avoid staying up late and overexertion

In addition to dietary factors, lifestyle also has an important impact on drug efficacy and tolerance. During treatment with selinesol, some patients may experience fatigue, weakness, or hypotension. Staying up late and overexerting can aggravate fatigue, reduce the body's tolerance to drugs, and affect recovery and immune function. Patients should maintain a regular schedule, ensure 7-8 hours of sleep per day, and engage in moderate gentle exercise, such as walking or stretching, to promote blood circulation and mental state.

In general, diet and life management during selinesol treatment are crucial to improving tolerance, reducing adverse reactions, and maintaining treatment effects. Patients should follow the principles of "light, balanced, cooked food, moderate amounts of high protein, avoid irritating drinks and staying up late", and develop individualized diet and life plans under the guidance of doctors and nutritionists. At the same time, if you encounter severe discomfort or adverse reactions, you should seek medical treatment in time to ensure safe and effective long-term treatment.

Reference link:https://www.drugs.com

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