What are the possible adverse reactions of Zotuximab/Veloximab?

Zolbetuximab (zolbetuximab)-Vyloy, as a new monoclonal antibody drug targeting the CLDN18.2 protein, has demonstrated a unique mechanism and clinical potential in the treatment of gastric cancer and gastroesophageal junction cancer and other digestive system malignant tumors. Like other anti-cancer drugs, although it shows good efficacy in some patients, it may also cause some adverse reactions during use, which is something that patients must fully understand before treatment.

According to data, the most common adverse reactions of zotuximab are mainly concentrated in the gastrointestinal tract, such as nausea, vomiting, and decreased appetite. These are related to the drug's target and the body's response to treatment. Most patients can be relieved after supportive treatment or dose adjustment, but for those with weak constitutions, it may have a certain impact on the quality of life. In addition, some patients will experience infusion-related reactions during the infusion process, manifesting as fever, chills, respiratory discomfort, or rash. Therefore, doctors usually take pretreatment measures before administration and strengthen monitoring during the infusion period.

In addition, a small number of patients may experience systemic reactions such as fatigue, diarrhea, anemia or electrolyte imbalance. These side effects usually require regular blood tests and clinical monitoring for timely detection and treatment. Because zotuximab is a new drug, some rare or adverse events that occur after long-term use are still under continuous observation. Therefore, during the treatment process, doctors will advise patients to strictly follow up on follow-up and actively report any abnormalities in the body.

From a treatment perspective, the occurrence of adverse reactions does not mean that the drug cannot be continued, but that tolerance needs to be improved through dose adjustment, supportive treatment, or combination with other management methods under the guidance of a doctor. With the accumulation of experience, doctors have become more and more mature in dealing with side effects.

Reference materials:https://www.astellas.com/en/news/29401