How much is the market price of a box of Capivasertib?

Capivasertib is an oral small molecule AKT kinase inhibitor that is a targeted anti-cancer drug. It exerts anti-tumor effects by inhibiting the activity of AKT, a key kinase in the PI3K/AKT signaling pathway, thereby blocking tumor cell proliferation and promoting apoptosis. The drug is mainly targeted at patients with hormone receptor-positive (HR+), HER2-negative (HER2-) breast cancer, especially those with locally advanced or metastatic cases accompanied by PIK3CA, AKT1 or PTEN gene changes. Carpisetin can be used in combination with endocrine therapy drugs such as fulvestrant to delay tumor progression and improve treatment efficacy.

In clinical application, the use of carpisetin needs to strictly follow the genotyping and pathological diagnosis results to ensure that the drug can accurately act on the target in the patient's body. It is typically used in patients with metastatic breast cancer whose disease has progressed despite at least one prior endocrine-based regimen, or who has relapsed within 12 months of completing adjuvant therapy. Such patients are often at risk of endocrine resistance. Intervention with AKT pathway inhibitors can enhance the sensitivity of tumor cells to endocrine drugs, thereby prolonging disease control time.

Regarding the market price, Carpiseti has been on the market for a short time in the domestic market. The specific selling price has not yet been fully disclosed. Therefore, patients need to consult the hospital pharmacy or professional doctor before purchasing. Referring to overseas markets, the original drug is available in European, American and Swiss versions. The common specification is 200mg*64 tablets, and the price per box is about 60,000 yuan. In order to reduce the financial burden, some patients will choose the Laos Lucius version of generic drugs. The price per box of the same specifications is about more than 3,000 yuan, and the drug ingredients are basically the same as the original drugs, but they still need to ensure that the source is regular. Large price differences are mainly affected by regional policies, exchange rates and market channels.

Reference materials:https://www.drugs.com/mtm/capivasertib.html