Is there a generic drug of odevixibat and its efficacy compared with the original drug?

Odevixibat is a drug used to treat **primary cholestatic liver disease (PFIC)< span>**The main mechanism of action of oral drugs is to reduce bile acid reabsorption by inhibiting intestinal bile salt transporter (IBAT/ASBT), thereby improving cholestasis and alleviating itching symptoms. At present, odexibat has been marketed in China, but it has not yet been included in the medical insurance system, so domestic patients still need to pay for the drug at their own expense.

In overseas markets, the common specifications of the original drug Ordesibat are 200mcg*30 tablets. Each box is priced at more than 40,000 yuan (affected by exchange rate fluctuations), which is relatively expensive. This type of original drug has complete clinical verification in terms of efficacy and safety, and can significantly improve the itching symptoms and liver function indicators of PFIC patients. It is currently one of the standard drugs for the treatment of this disease.

At the same time, generic drugs of odexibat have also appeared in overseas markets, mainly versions made in Laos. For example, the generic drug price of 400mcg*30 tablets produced by Laos Lucius is about 3,000 yuan, and the price of generic drugs produced by Laos ASEAN Pharmaceutical is 200mcg*30 tablets or 1200mcg*30 tablets The price of generic drugs is even lower, only more than 500 yuan (also affected by the exchange rate). The ingredients of these generic drugs are basically the same as those of the original drugs. In theory, they are not much different from the original drugs in terms of efficacy and safety. However, it is still recommended to use them under the guidance of a doctor and pay attention to the treatment response.

Generally speaking, odexibat shows obvious price differences and consistent ingredients between the original drug and generic drugs. For patients with limited financial conditions or long-term treatment, choosing regular generic drugs can significantly reduce the financial burden, but it is still necessary to ensure that the source of the drugs is regular and of reliable quality, and at the same time, individualized dosage adjustments are made under the guidance of professional doctors to ensure efficacy and drug safety.

Reference link:https://www.drugs.com