Storage and transportation temperature requirements and precautions for abatacept (Enrisu)

Abatacept is a recombinant fusion protein biological agent used to treat rheumatoid arthritis, juvenile idiopathic arthritis and some autoimmune diseases. Since it is a protein drug and is very sensitive to temperature and storage conditions, correct storage and transportation are crucial to ensure drug activity and efficacy.

Normally, abatacept needs to be stored refrigerated at a temperature of 2–8℃ to avoid freezing. In home or hospital pharmacies, they should be placed in a dedicated pharmaceutical refrigerator and avoid direct contact with ice to prevent local freezing from causing protein denaturation or precipitation, thereby affecting the efficacy. Refrigerated storage can ensure that abatacept maintains stable activity and safety during its validity period.

During transportation, abatacept should also be strictly kept at low temperature. During transportation, drugs should use temperature-controlled transport boxes or refrigerated transport containers to ensure that the temperature is within the range of 2–8°C to avoid high temperature exposure or freezing. If a drug is accidentally exposed to room temperature or excessively high temperatures during transportation, professionals should determine whether it can still be used to prevent the drug from decreasing in efficacy or causing safety issues.

In addition, the appearance of abatacept solution should be checked before use to ensure that there is no discoloration, turbidity or precipitation. If any abnormality is found, stop using it and contact your doctor or pharmacist. After opening, the injection solution or injection pen should be used within the specified time as much as possible and should not be exposed to room temperature for a long time. Complying with the above storage and transportation requirements can ensure the efficacy and safety of abatacept to the greatest extent.

Reference link:https://www.drugs.com