How many times a day should you take selegiline/midopir?

Selegiline/midopid (Selegiline) has a relatively clear dosage regimen in clinical use. Doctors usually adjust the dosage according to the patient's condition and whether it is combined with levodopa treatment. It is generally recommended that the initial dose is 5 mg orally taken in the morning, that is, one tablet. After observing the patient's tolerance and efficacy, the dose can be adjusted to 10 mg per day. You can choose to take it once in the morning, or once in the morning and at noon. Since the drug has a central stimulant effect, it is usually not recommended to take it in the afternoon or evening to avoid insomnia.

In the early stages of Parkinson's disease, some patients can achieve certain improvement in motor symptoms using selegiline alone. But more often, selegiline is combined with levodopa. When patients take levodopa concomitantly, if similar levodopa-related adverse reactions occur, such as nausea, arrhythmia, or worsening of dyskinesia, clinicians may reduce the dose of levodopa while continuing to maintain selegiline to achieve therapeutic balance. The advantage of this combination is that it prolongs the duration of action of levodopa and reduces the adverse reactions caused by its peak dose.

During the specific medication process, patients should not adjust the dosage by themselves. If you need to increase or decrease the dose, you should follow your doctor's advice, because there is a risk of interaction between MAO-B inhibitors and a variety of drugs (such as antidepressants, certain analgesics), and unreasonable combinations may cause serotonin syndrome or hypertensive crisis. Especially for elderly patients or individuals with cardiovascular disease, it is even more necessary to strictly follow professional guidance.

When using selegiline for a long time, doctors usually recommend that patients return for regular follow-up visits to monitor improvements in motor function and whether side effects occur. Some people may experience mild gastrointestinal reactions or insomnia. At this time, adjusting the medication time can often improve tolerance. For patients whose curative effect is maintained well, the therapeutic purpose can be achieved by taking it once a day or in divided doses.

Reference: https://www.drugs.com/mtm/selegiline.html