What is the dosage of Acotiamide?

Acotiamide is a drug specifically targeted at functional dyspepsia. It helps reduce symptoms such as postprandial fullness, epigastric discomfort, and early satiety by improving gastric compliance and motility. Its mechanism of action is different from traditional prokinetic drugs. Acotiamide mainly promotes the coordinated movement of gastric smooth muscles by regulating the release of neurotransmitters such as acetylcholine, allowing food to pass through the stomach more smoothly. This mode of action not only improves patients' symptoms, but also reduces side effects caused by over-stimulation of the gastrointestinal tract.

In terms of clinically recommended usage and dosage, the common dosage for adult patients is 100 mg each time three times a day, usually taken orally before three meals. When taking the medicine, the tablet should be swallowed whole and should not be chewed or broken to ensure normal release and absorption of the medicine in the digestive tract. It is recommended to take it with warm water to achieve the best effect. Since its pharmacodynamic mechanism is closely related to dietary status, taking it before meals can better play the role of the drug in regulating gastric motility. If the patient's symptoms have not improved after 1 month of continuous treatment, you should consider stopping use or changing the treatment plan to avoid delaying the condition with long-term ineffective medication. At the same time, if the symptoms are significantly relieved, it is not recommended to use it indefinitely. The doctor's guidance should be followed and the drug should be gradually discontinued according to the recovery situation.

It should be emphasized that acotiamide is suitable for patients with functional dyspepsia, and not all dyspepsia is suitable for use. If symptoms persist or worsen, organic diseases such as gastric ulcer and gastric cancer must be ruled out. Therefore, it is best for patients to undergo gastroscopy or related examinations before taking medication. Acotiamide is not suitable for long-term use without medical supervision as it may mask underlying serious medical conditions. In addition, there are insufficient data on the use of this drug in children and pregnant women, so it is currently mainly recommended for use in adult patients.

Reference: https://www.rad-ar.or.jp/siori/english/search/result?n=33322