How much does enzalutamide/enzalutamide cost on the market?

Enzalutamide/Enzalutamide ( Enzalutamide) is a new generation of androgen receptor inhibitor, mainly used to treat castration-resistant prostate cancer (CRPC) and some patients with metastatic prostate cancer. Different from traditional endocrine therapy drugs, enzalutamide has a triple effect in pharmacological mechanism. On the one hand, it can block the binding of androgens to receptors, on the other hand, it can prevent receptors from entering the cell nucleus. It can also inhibit the transcriptional activity of cancer cells. Therefore, it is clinically considered to be a more advanced treatment option for prostate cancer patients. In recent years, with the increase in the incidence of prostate cancer worldwide, the clinical application of enzalutamide has gradually expanded in many countries and regions, and has become one of the key drugs recommended in multiple guidelines.

In the Chinese market, enzalutamide’s original drug is marketed in the form of soft capsules, with a common specification of 40mg*112 capsules/box. After medical insurance negotiations, the drug was included in the reimbursement scope of Class B medical insurance, allowing patients to obtain treatment at a relatively controllable price. The current price of a box of enzalutamide in the domestic market is about 5,000 yuan, but due to the support of medical insurance policies, the actual out-of-pocket portion paid by patients may be lower than the listed price, further reducing the financial burden. In contrast, there is a large price gap between drugs of the same specifications in overseas markets. For example, in Turkey, the price in local pharmacies may exceed RMB 10,000, while prices in some European countries are also at relatively high levels. This is related to local medical insurance systems and exchange rate fluctuations.

It is worth noting that in addition to the original drugs, there are also generic drugs on the market in Laos, India and other places. Their active ingredients are basically the same as the original drugs and their curative effects are similar. The selling price of generic drugs is significantly lower than that of original drugs, and in some areas the price is even more than 2,000 yuan per box. However, it is usually difficult for this type of generic drugs to enter the Chinese mainland market, and most of them are distributed through overseas channels. Patients should pay attention to the legal compliance of drug sources and drug quality assurance when choosing.

Reference materials:https://www.xtandi.com/