What are the functions and effects of ruxolitinib tablets/Jiekewei?

Ruxolitinib tablets/Ruxolitinib is a small molecule inhibitor targeting JAK1/JAK2. It mainly acts on the JAK-STAT signaling pathway to regulate blood cell production, inflammatory response and immune system activity. Its core mechanism of action is to inhibit abnormal JAK tyrosine kinase signaling, reduce the release of pro-inflammatory cytokines, and inhibit the proliferation of abnormal hematopoietic cells, thereby improving patient symptoms and delaying disease progression.

In patients with myelofibrosis (MF), ruxolitinib can effectively control spleen enlargement, improve bone marrow hematopoietic dysfunction, reduce patients' systemic symptoms such as fatigue, tiredness, night sweats and weight loss caused by anemia or white blood cell abnormalities, thereby improving the quality of life. For patients with polycythemia vera (PV), ruxolitinib can reduce blood viscosity and the risk of blood clots caused by excessive red blood cell production, improve symptoms such as headache, dizziness and skin itching, and help patients maintain stable blood parameters.

In addition, ruxolitinib has shown significant efficacy in the treatment of graft-versus-host disease (GvHD), especially in patients who have failed previous corticosteroid therapy. Its mechanism of action is by inhibiting abnormal immune cell activation and the release of inflammatory factors, thereby alleviating skin, liver and digestive tract related symptoms, improving patients' quality of life, and reducing the risk of long-term complications.

Ruxolitinib is an oral medication that facilitates long-term maintenance treatment, which is particularly important in the management of chronic hematological diseases and transplant-related complications. Clinically, doctors will develop an individualized dosage plan based on the patient's blood indicators and symptom severity, while regularly monitoring hematology, liver and kidney function to ensure maximum efficacy and reduce the risk of adverse reactions. Patients must strictly follow the doctor's instructions during medication, maintain regular medication, and pay attention to potential side effects, such as thrombocytopenia, anemia, increased risk of infection, etc.

Reference materials:https://www.jakavi.com/