What is the correct way to take resmetirom?

In the treatment of non-alcoholic steatohepatitis (NASH), the application of resmetirom (resmetirom)-Rezdiffra is gradually becoming popular, and the correct method of taking it directly affects the efficacy and safety. At present, overseas markets mainly provide three specifications: 60mg 30 tablets, 80mg 30 tablets and 100mg*30 tablets. Doctors usually make individual dosage adjustments based on the patient's actual body weight (ABW).

According to internationally accepted recommendations, patients weighing less than100 kilograms can achieve the desired effect by taking 80 mg orally once a day in most cases. For people weighing more than or equal to 100 kilograms, it is recommended to take 100 mg once a day to ensure that the drug concentration is sufficient to regulate liver lipid metabolism. Regardless of the dose, it should be taken at a fixed time as much as possible to maintain a stable drug concentration in the body.

It is important to note that rismetirol is designed for long-term use and works best when combined with diet and exercise. NASH is a chronic progressive disease, and it is difficult to achieve lasting effects with drug intervention alone. When patients cooperate with controlling total caloric intake and increasing aerobic and resistance training, the effect of drugs in improving liver fibrosis will be more significant. Therefore, doctors often recommend that patients continue to maintain a healthy lifestyle while taking the medication.

During the course of taking it, patients should not increase or decrease the dose or interrupt treatment at will. If the dose is interrupted due to a missed dose, the dose should be taken as soon as possible, but do not take too much at one time to make up for the missed dose. Some patients may experience mild digestive discomfort or fluctuations in thyroid function indicators in the early stages of medication, but this is usually within a controllable range and can be monitored as directed by the doctor.

It is worth emphasizing that Resimeterol has not yet been launched on a large scale in China. If domestic patients need medication, they can purchase the European version or the original Hong Kong version through formal and legal overseas channels. When choosing a channel, be sure to ensure the genuine source of the medicine to avoid counterfeit or substandard medicines that may affect the therapeutic effect.

Reference materials:https://www.drugs.com/monograph/resmetirom.html