Usage and dosage of Japanese tinnitus reliever

Japanese tinnitus reliever is a drug used to relieve tinnitus caused by dysfunction of the inner ear and central nervous system. Its main ingredients are nicotinamide and pipebatinium hydrochloride. The drug is available in Japan, but has not yet been launched in China. Its use must be through formal channels and follow the guidance of a doctor. This article will introduce in detail the usage and dosage, pharmacokinetic properties, and medication precautions for special groups of tinnitus relievers in Japan, to help patients use the drugs correctly and reduce potential risks.

Usage and dosage of Japanese tinnitus reliever

Correctly mastering the usage and dosage of Japanese tinnitus reliever can reduce the occurrence of adverse reactions, and it needs to be used under the guidance of a doctor.

General Usage

The recommended dosage for adults is 2 tablets each time, 3 times a day, taken after meals. The medicine should be taken with warm water and avoid taking it with irritating drinks. When taking, the tablets should be completely removed from the aluminum-plastic plate to prevent accidental swallowing of the packaging.

Dose adjustment

Based on the patient’s age, severity of symptoms and individual response, the dose can be increased or decreased appropriately under the guidance of a doctor. Those with mild symptoms can try reducing the dose to 1 tablet each time, while those with severe symptoms should not increase the dose on their own.

Dose time

It is recommended to take the medicine at a fixed time every day to keep the blood concentration stable. If you miss a dose, you should take it as soon as you remember. If it is close to the time of the next dose, skip it. Do not take a double dose.

Pharmacokinetics of tinnitus relievers in Japan

Understanding the absorption, distribution, metabolism and excretion processes of drugs can help predict their efficacy and potential interactions.

Absorption characteristics

The drug is absorbed through the gastrointestinal tract after oral administration. The bioavailability of nicotinamide and pipebamium hydrochloride is less affected by food, but taking it after a meal can reduce gastric discomfort. The onset of effect is approximately 30-60 minutes.

Metabolism pathway

Nicotinamide is mainly metabolized by the liver into N-methylnicotinamide, and pipebatinium hydrochloride is metabolized by the liver cytochrome P450 enzyme system. Both metabolites have no significant pharmacological activity.

Excretion mode

Metabolites are mainly excreted through the kidneys and a small amount through bile. Patients with renal insufficiency may need to adjust the dosage, and patients with abnormal liver function should use with caution.

Special population use of tinnitus alleviation drugs in Japan

People with different physiological conditions have different responses to drugs, which requires special attention.

Elderly patients

The liver and kidney functions of the elderly may be reduced. It is recommended that the starting dose be halved and adverse reactions should be closely monitored. If symptoms such as dizziness or drowsiness occur, you should seek medical treatment promptly.

Pregnant and lactating women

Pregnant women should only use it when the expected benefits outweigh the risks. Lactating women are advised to suspend breastfeeding while taking the drug. When necessary, it should be used under the supervision of a professional physician.

Pediatric patients

No safety and efficacy data have been established for people under 18 years of age, and use by children is not recommended. If it is really necessary to use it, it must be decided after strict evaluation by a specialist.