盐酸纳洛酮鼻喷雾剂的具体使用步骤和注意事项？

Many patients with opioid overdose may buy or use naloxone hydrochloride nasal spray for emergency treatment, but they are not clear about the specific steps of use, use it irregularly, and feel that the drug has no effect. Therefore, it is necessary to understand the specific steps of using Naloxone Hydrochloride Nasal Spray, and also know in advance what you need to pay attention to during the medication, so as to avoid not knowing how to deal with it after taking the medication.

A drug that can quickly reverse an opioid overdose is an opioid antagonist, meaning it attaches to opioid receptors and reverses and blocks the effects of other opioids. If breathing has slowed or stopped due to an opioid overdose, naloxone can quickly restore normal breathing.

Indications of Naloxone Hydrochloride Nasal Spray

1. It is suitable for emergency treatment of known or suspected opioid overdose, manifested by respiratory or central nervous system depression.

2. Anticipate immediate administration as emergency treatment in situations where opioids may be present.

Specific steps for using naloxone hydrochloride nasal spray

1. Preparation before use

1. Take out the naloxone nasal spray from the package.

2. Make sure not to remove or test the spray.

3. Each spray package contains a single dose of naloxone and cannot be reused.

2. Medication steps

1. The patient lies supine and receives a dose of naloxone hydrochloride nasal spray.

2. Take out the Naloxone Hydrochloride Nasal Spray from the box, use a circle to peel back the tab, and open the Naloxone Hydrochloride Nasal Spray.

3. Hold the bottom of the red plunger of the naloxone hydrochloride spray with your thumb, and hold both sides of the nozzle with your index and middle fingers.

4. Tilt the patient's head back and support the lower part of the neck with your hands. Gently insert the tip of the nozzle into one nostril until your fingers rest against the base of the person's nose on either side of the nozzle.

5. Press the red plunger firmly to give the dose of naloxone hydrochloride nasal spray.

6. Take out the naloxone hydrochloride nasal spray from the nostril after administration.

7. After administering naloxone hydrochloride nasal spray, place the patient on his side and observe the patient closely. Another dose may be given if the patient is awake, unresponsive to sound or touch, or breathing normally. Naloxone hydrochloride nasal spray can be administered every 2-3 minutes. Repeat steps 2-6 using a new dose of naloxone hydrochloride nasal spray in the other nostril until the patient responds or receives emergency medical help.

8. Put the used naloxone hydrochloride nasal spray back into the box.

9. Discard used naloxone hydrochloride nasal spray away from children.

Precautions for use of naloxone hydrochloride nasal spray

1. Risk of recurrent respiratory and CNS depression: Due to the duration of action of naloxone hydrochloride relative to opioids, continue to monitor the patient and, if necessary, repeat the administration of naloxone hydrochloride using a new nasal spray while awaiting emergency medical assistance.

2. Risk of limited efficacy of partial agonists or mixed agonists/antagonists: The reversal of respiratory depression caused by partial agonists or mixed agonists/antagonists, such as buprenorphine and pentazocine, may not be complete, and larger doses or repeated administration may be required.

3. Precipitation of severe opioid withdrawal: Use by patients with opioid dependence may trigger opioid withdrawal. In newborns, opioid withdrawal can be life-threatening if not recognized and appropriately treated; monitor for the development of opioid withdrawal.

4. Risk of cardiovascular (CV) effects: Sudden postoperative reversal of opioid suppression may lead to adverse CV effects. These events occur primarily in patients with pre-existing CV disease or receiving other drugs that may have similar CV adverse effects. Monitor these patients closely in the appropriate health care setting after administration of naloxone hydrochloride.

The price of Naloxone Hydrochloride Nasal Spray (Narcan)

Currently, we know that the reference price of Naloxone Hydrochloride Nasal Spray (Narcan) is approximately US$257 per box. According to the current exchange rate, it is approximately between 1856$-2000$ when converted into RMB. But if the exchange rate changes, its price will also change.

The price of naloxone hydrochloride nasal spray also depends on where you get it, how you get it, and the type you get it. Patients with insurance should check with their insurance company to see if this drug is covered. Uninsured patients can check retail prices at their local pharmacy or hospital. In addition, some pharmaceutical companies have developed cost assistance programs for patients who cannot afford the fees. You can consult them yourself.

Naloxone hydrochloride nasal spray should be used strictly in accordance with the drug instructions or under the guidance of a doctor. If you have any questions about the method of use, or do not understand the specific operating steps, it is recommended to consult a professional doctor in a regular hospital and do not use the medicine blindly. When using opioids for treatment, it is necessary to pay close attention to the condition and blood drug levels in order to respond to overdose.

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