阿福他酶α最新公布价格表

Afotalase α is an important enzyme replacement therapy for specific genetic metabolic diseases. It is suitable for patients with definite diagnosis of fetal, infant or adolescent-onset hypophosphatasia; patients of all ages (from newborns to adolescents), its price, drug preparation strategy and medication regimen for special groups are crucial to patient treatment. This article will provide a detailed analysis from three aspects: the latest pricing, reasonable drug quantities, and medication precautions for special groups, to provide a reference for clinical medication.

The latest published price of aftase alpha

There are significant differences in the prices of different specifications, and the prices are for reference only.

Standard specification price

The price of 18mg/0.45mL/box of aftase α is approximately US$13,205. This specification is suitable for adult standard dose treatment and requires 2-3 boxes per month.

Other specifications

Afotalase α is also available in 28mg/0.7mL/box, 40mg/mL/box or 80mg/0.8mL/box. The prices vary depending on the specifications.

The price of aftase alpha is affected by many factors, such as drug specifications, exchange rates, purchase channels, etc. Patients need to refer to the actual price at the time of purchase.

The number of preparations for aftase alfa

Reasonable planning of the quantity of preparations requires comprehensive consideration of factors such as the treatment plan, storage conditions, and drug validity period.

Calculated based on treatment cycle

The typical treatment regimen for adults is 1 mg/kg per week. A 60kg patient needs about 240mg per month, which is 14 boxes of standard specifications. It is recommended to keep a certain margin for dose adjustment.

Cold chain storage restrictions

Aphthase α needs to be refrigerated at 2-8°C, and a maximum of 6 boxes can be stored in a household refrigerator. Preparing a large amount of medicine requires a professional medical refrigerator, and a single purchase should not exceed 3 months' supply.

Emergency reserve recommendations

In addition to regular medication, an additional 2 weeks of doses should be reserved as emergency backup.

Regularly check drug inventory and validity period, and establish a "first in, first out" management system for drug turnover.

Usage of aftase α for special groups

Different groups of people need to develop individualized dosing plans for aftase α. The following are key precautions.

Principles of medication for pregnant women

No teratogenicity has been found in animal experiments, but there is a lack of human data. Use only when the expected benefits outweigh the risks, and monitor fetal development closely during treatment.

Key points for breastfeeding decisions

Weigh the potential risks of medications against the benefits of breastfeeding. If medication is needed, it is recommended to suspend breastfeeding within 6 hours after medication, or consider temporarily switching to formula feeding.

Children’s dose adjustment

Suitable for newborns to adolescents, adjust the dose according to body weight. Special attention should be paid to infusion reactions, and it is recommended that the first dose be completed under hospital supervision.

Elderly patients should start with a low dose, slowly titrate to the target dose, and closely monitor changes in liver and kidney function.