阿福他酶α国内能买到吗？在哪能买到？

Asfotase alfa is an enzyme replacement therapy drug suitable for hypophosphatasia (HPP). It is developed by Alexion Pharmaceuticals (Alexion) of the United States and its trade name is Strensiq. As of June 2025, the drug has not been officially approved for marketing in mainland China, so it cannot be purchased directly from regular domestic hospital pharmacies. If patients need to obtain aftase alfa, they need to purchase the drug through a medical service institution.

Is aftase α available in China

As of June 2025, it has not been officially approved for marketing in mainland China, so it cannot be purchased directly from regular domestic hospital pharmacies. If patients need to obtain the drug, they need to rely on overseas channels.

Domestic Approval Status

Afotalase α is still in the domestic clinical research stage and has not yet received marketing approval from the National Medical Products Administration (NMPA). Many domestic medical institutions are conducting relevant clinical trials to evaluate its efficacy and safety in Chinese patients.

Temporary import possibility

Some hospitals may provide aftase alpha to urgently needed patients through "temporary import", but strict conditions must be met, including diagnosis certificate, doctor application and hospital approval. This method is complex and expensive.

Since it has not yet been officially launched in China, patients face great difficulties in purchasing aftase alpha. We hope that the drug will be approved as soon as possible in the future to benefit more Chinese patients.

Where can I buy aftase α?

Currently, domestic patients can obtain aftase α through the following channels, but they need to be careful to choose formal channels to avoid buying fake and shoddy products.

Purchase in regular overseas pharmacies

Patients can go to regular hospitals or pharmacies in countries where aftase α has been marketed (such as the United States, Japan, and some European countries) to purchase it with a doctor's prescription. This method has a reliable source of medicines, but international travel or mailing costs are incurred.

Medical service institutions

Some qualified international medical service institutions can provide aftase α purchase service, and the price is approximately RMB 46,700 per box. When choosing a purchasing agent, you need to verify the platform’s qualifications to ensure the authenticity of the drugs.

Clinical trial participation

Some domestic medical institutions are conducting clinical trials of aftase alpha. Eligible patients can apply to participate and receive free drug treatment. This method needs to meet strict admissions criteria.

No matter which purchasing channel is chosen, patients should proceed under the guidance of a doctor and retain complete drug purchase receipts and drug information for inspection.

Precautions for the use of aftase α

Afotalase α must be used strictly in accordance with the doctor's instructions. The following are the key medication precautions.

Correct injection method

Afotalase α needs to be injected subcutaneously. The recommended dose is 6 mg/kg per week, which can be divided into 2 mg/kg 3 times a week or 1 mg/kg 6 times a week. Injection sites should be rotated (abdomen, thigh, upper arm, etc.) to avoid local reactions.

Adverse reaction monitoring

Common adverse reactions include injection site reactions (redness, swelling, pain), allergic reactions and bone changes. Renal function and calcium and phosphorus metabolism indicators need to be monitored regularly during treatment. If serious adverse reactions occur, seek medical attention immediately.

Usage for special groups

Pregnant women are prohibited from taking Aftase α; lactating women need to suspend breastfeeding when taking the drug; children need to accurately calculate the dose based on body weight; elderly patients and those with renal insufficiency need to adjust the dose.

Afotalase α needs to be stored refrigerated at 2-8°C, avoiding freezing or direct sunlight. Patients should strictly follow the drug instructions and doctor's instructions to ensure safe and effective medication.