阿福他酶α(asfotase alfa)的不良反应和副作用

Asfotase alfa is an effective treatment for hypophosphatasia (HPP), but its clinical application requires attention to potential side effects.

Side effects of afotase alfa that require immediate medical attention

Asfotase alfa may cause adverse reactions while exerting its therapeutic effect. If serious side effects occur, timely medical intervention is required:

1. Common side effects

Afotase alfa (asfotase alfa) may cause adverse reactions. alfa) may cause adverse reactions: hematuria; chest tightness; dimpling, indentation, or thickening of the skin at the injection site; difficulty or pain during urination; dry or red eyes; fast heartbeat; fever; hives, itching, or rash; hoarseness; irritation; joint pain , stiffness or swelling; nausea; pain in the groin or genitals; redistribution or accumulation of body fat; redness of the skin; dark spots or matter floating in front of the eyes; severe back pain under the ribs; swelling of the eyelids, face, lips, hands, or feet; difficulty breathing or swallowing; vomiting. If the above symptoms occur, please seek medical treatment promptly.

2. Rare side effects

Afotase α (asfotase alfa) may cause chills; clay-colored stools; confusion; dark urine; diarrhea; dizziness; fever; headache; irregular heartbeat; loss of appetite; mood or mental abnormalities; muscle spasms in the limbs or face; numbness and tingling around the mouth, fingertips, or feet; seizures; abdominal cramps; tremor; abnormal bad breath; extreme fatigue; vomiting blood; jaundice (yellowing of the skin or sclera). If the above symptoms occur, please seek medical attention immediately.

3. The incidence is unknown

During asfotase alfa treatment, you need to be alert to increased difficulty in breathing, increased difficulty in walking, and new pain or swelling in the arms or legs without trauma. The above symptoms may indicate disease progression or adverse drug reactions. It is recommended to contact the attending physician immediately for evaluation.

Side effects of afotase alfa that require immediate consultation with a doctor

Afotase alfa (asfotase alfa) may cause some side effects that do not require medical care. Most reactions during the adaptation period of medication can be alleviated through self-management. As the medication time is prolonged, these symptoms will usually reduce on their own. If symptoms persist, consult your doctor immediately:

Asfotase alfa may cause bleeding, blistering, burning, coldness, skin discoloration, pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, stinging, ulceration, or warmth at the injection site. If symptoms persist, consult your doctor immediately.

Side effects of aftase alpha for medical personnel's reference

1. Hypersensitivity reaction

(1) Very common (10% or more): Hypersensitivity reaction (12%).

(2) Uncommon (0.1%-1%): allergic reaction symptoms.

2. Local adverse reactions

Very common (10% or more): injection site reactions (63%), lipodystrophy (28%).

3. Nephrotoxicity

Unreported frequency: nephrocalcinosis, kidney stones.

4. Ocular toxicity

Unreported frequency: extraocular calcification.

5. Hepatotoxicity

Unreported frequency: chronic hepatitis

6. Immune problems

Unreported frequency: anti-drug antibodies

7. Metabolism

Unreported frequency: hypocalcemia, reduced vitamin B6