非布索坦（非布司他）的适应症

What are the indications? Let’s find out below.

Febuxostat (Febuxostat) is an effective non-purine selective inhibitor of xanthine oxidase XO. It achieves the therapeutic effect of reducing serum uric acid by selectively inhibiting xanthine oxidase. Uric acid is the end product of purine metabolism and is produced in the cascade reaction of hypoxanthine → xanthine → uric acid. Each step of the conversion is catalyzed by xanthine oxidase. Febuxostat has been shown to effectively inhibit both the oxidized and reduced forms of xanthine oxidase. Febuxostat (Febuxostat) at therapeutic concentrations does not inhibit other enzymes involved in purine or pyrimidine metabolism, namely guanine deaminase, hypoxanthine guanine phosphoribosyltransferase, orotate phosphoribosyltransferase, orotate monophosphate decarboxylase, or purine nucleoside phosphorylase. 

Indications of Febuxostat: Clinically used for gout and gouty nephropathy. This product is effective for patients who are ineffective or intolerant to drugs that promote uric acid excretion. Not recommended for use in asymptomatic hyperuricemia. 

In addition, the U.S. Food and Drug Administration (FDA) issued a safety information warning for the gout drug febuxostat, believing that it may increase the risk of cardiovascular death and all-cause death. 

The FDA pointed out that patients who have failed or are intolerant to allopurinol can still use febuxostat (febuxostat), but doctors should inform patients of the cardiovascular risks of febuxostat and advise them to seek immediate medical attention if they experience the following symptoms: chest pain, shortness of breath, fast or irregular heartbeat, numbness or weakness on one side of the body, dizziness, difficulty speaking, or sudden severe headache. 

When the FDA approved Febuxostat (Febuxostat) for clinical use in 2009, it added a warning about possible cardiovascular events to the prescribing information. This update of the warning was based on the results of the post-marketing safety study CARES.

The above are all the indications provided by our Medical Companion Travel Overseas Medical Consulting Service Company.