去纤维钠效果好吗？

(Defibrinoside defiteli) is a single-stranded oligonucleotide mixture with anti-thrombotic and fibrinolytic effects. It is a DNA-derived anticoagulant used in the treatment of hepatic veno-occlusive disease and hematopoietic stem cell transplantation for renal or pulmonary insufficiency. It was approved for marketing in the United States in 2016.

Defibrotide sodium is a new drug for the treatment of hepatic veno-occlusive disease (HVOD). It has the effects of anticoagulation, promoting fibrinolysis, and promoting vascularization. But for domestic patients, the name defibrinated sodium is relatively unfamiliar. Let’s take a look at the effect of defibrinated sodium.

Defibrotide sodium (Defibrotide defiteli) is currently recognized as the most promising new drug for the treatment of hepatic veno-occlusive disease (HVOD) after hematopoietic stem cell transplantation (HSCT). By reducing the expression of cell adhesion molecules on the surface of endothelial cells, it can reduce the adhesion of leukocytes to vascular endothelial cells and reduce the inflammatory damage of endothelial cells.

In vitro experiments and in vivo animal experiments have confirmed that defibrinated sodium can stimulate the release of prostacyclin PGI2. PGI2 is mainly synthesized and secreted by vascular endothelium and platelets. It dilates blood vessels and inhibits platelet aggregation by increasing the level of cAMP. Defibrotide sodium can significantly increase the expression of thrombin regulatory protein (TM) and tissue factor pathway inhibitors to produce anticoagulant effects.

Richard Pazdur, M.D., director of the Office of Hematology and Oncology Products in the FDA's Center for Drug Evaluation and Research, said: "The approval of defibrotide (defiteli) fills a huge need for patients with rare but often fatal complications after receiving chemotherapy and HSCT."

The above is an introduction to the effect, I hope it will be helpful to you. If you have other questions, you can continue to consult the medical companion passenger service for answers.