去纤苷的注意事项有哪些呢？

Defibrinoside (defiteli) has anti-thrombotic, fibrinolytic, anti-ischemic, and anti-infective effects in vivo and in vitro. Defibrotide was approved for marketing in the European Union in October 2013, and was approved for marketing in the United States by the U.S. Food and Drug Administration (FDA) on March 30, 2016. It is suitable for the treatment of adult and pediatric patients with hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), and renal or pulmonary dysfunction after hematopoietic stem cell transplantation (HSCT).

The recommended dose of defibrotide for adult and pediatric patients is 6.25 mg/kg given every 6 hours as a 2-hour intravenous infusion. Defibrotide was administered for a minimum of 21 days. If signs and symptoms of hepatic VOD have not resolved after 21 days, continue defibrotide until resolution of VOD or up to a maximum of 60 days.

What are the precautions for defibrination?

1. Defibrotide must be diluted before infusion.

2. Before administration of defiteli, confirm that the patient has not experienced clinically significant bleeding and is hemodynamically stable on no more than one vasopressor.

3. Do not co-administer defibrotide and other intravenous drugs in the same intravenous line at the same time.

4. Concomitant use of defibrotide (defiteli) and a systemic anticoagulant or fibrinolytic therapy (excluding use for routine maintenance or central venous line reopening) may increase the risk of bleeding. Discontinue anticoagulants and fibrinolytics before defibrotide therapy, and consider delaying initiation of defibrotide administration until the effects of the anticoagulant have lessened.

5. Hypersensitivity reactions have occurred in less than 2% of patients treated with defibrotide. These reactions include rash, urticaria, and angioedema.

The above are some precautions for defibrotide. Patients need to strictly follow the doctor's instructions during the medication. If they have other conditions, they should explain to the doctor in time and choose treatment according to the doctor's judgment.