去纤苷2020年最新价格

What is the latest price of defibrotide (defiteli sodium, defiteli) in 2020? Recently, many patients have asked about the price of defibrotide (defiteli). Let’s take a look at it together. Defibrotide (defiteli) is a single-stranded oligonucleotide mixture with anti-thrombotic and fibrinolysis-promoting effects. In recent years, multiple clinical research results have shown that defibrotide (defiteli) is a safe and effective drug for preventing and treating HVOD after HSCT. Defibrotide (defiteli) is an adenosine receptor agonist with multiple effects. The adenosine A1/A2 receptors of endothelial cells are involved in the regulation of endothelial cells and the response of endothelial cells to injury. Defibrotide (defiteli) can act on these receptors to produce a variety of downstream effects. Defibrotide (defiteli) can also reduce the expression of cell adhesion molecules on the surface of endothelial cells, thereby reducing the adhesion of leukocytes to vascular endothelial cells and reducing the inflammatory damage of endothelial cells.

In addition, defibrotide (defiteli) can also promote the release of prostaglandin I2 (PGI2) and prostaglandin E2 (PGE2), thereby causing blood vessel dilation, inhibiting platelet aggregation, and reducing ischemic damage. Studies have shown that defibrotide (defiteli) can significantly increase the expression of thrombin regulatory protein (TM) and tissue factor pathway inhibitors to produce anticoagulant effects.   

Defibrotide (defiteli) was first developed by Gentium Pharmaceuticals in Italy and was approved for marketing in the EU in October 2013. After Gentium Pharmaceuticals was acquired by Jazz Pharmaceuticals of the United States, defiteli (defiteli) was approved by the US Food and Drug Administration (FDA) to be launched in the United States on March 30, 2016, under the trade name Defitelio. In terms of price, defiteli (defiteli) costs tens of thousands of dollars in RMB equivalent internationally; while defiteli (defiteli) has not been approved for marketing in mainland China, it has been approved for listing in Hong Kong, and its price is almost the same as internationally. In addition, patients can obtain a cost-effective version of defiteli (defiteli) through domestic professional overseas medical service organizations (such as Medical Companion Travel), priced at about 22,000 US dollars per box.