去纤维钠治疗肝小静脉闭塞病效果怎样？

It is an adenosine receptor agonist with multiple effects. It was approved for marketing in the United States in 2016 and is known as an "orphan drug". It is also the first drug approved by the US FDA to treat severe hepatic venous occlusion. It was developed by Gentium Pharmaceuticals (later acquired by Jazz Pharmaceuticals of the United States). It is also known as defibrotide.

Sodium defibrination has not yet been approved for marketing in my country, and it is still somewhat unfamiliar to domestic patients. Let’s take a look at the effect of sodium defibrination in treating hepatic veno-occlusive disease.

The effectiveness of defibrinated sodium in pediatric patients comes from an analysis of a retrospective clinical study. The 45 post-HSCT HVOD patients included in the study were all younger than 20 years old, with a median age of 8.2 years (0.2-20 years). Defibrinated sodium was administered daily at 10~110 mg/kg by intravenous infusion, and the median usage time was 17 days (1-83 days). The results showed that the CR rate was 76%, and the OS rate 1,00 days after transplantation was 64%. Among them, the CR rate of 22 SHVOD patients was 50%, and the OS rate 100 days after transplantation was 36%. This study not only confirmed the effectiveness of defibrotide sodium in the treatment of HVOD in children, but also showed that the addition of other drugs for the treatment of HVOD does not affect the efficacy of defibrotide sodium in the treatment of HVOD.

It has anti-thrombosis, promoting fibrinolysis, anti-ischemia, anti-infection and other effects in vivo and in vitro. Both adults and children should take the drug in the correct way. For children and adults treated with defibrotide, the injection dose is based on body weight. The recommended dose is 6.25 mg/kg given every 6 hours as a 2-hour intravenous infusion. The minimum period of administration of defibrinated sodium is 21 days. If the patient has special circumstances, he or she should inform the doctor before treatment. Correct use of medication can maximize the therapeutic effect.

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