去纤维钠用途和价格

(Defitelio) is a biochemical drug derived from a mixture of single-chain deoxyoligonuclear acids. It mainly acts on endothelial cells and produces a variety of biological effects. Clinical research is mainly carried out around the indications of cardiovascular dysfunction. Clinical experiments have proven that defibrotide can effectively prevent and treat hepatic veno-occlusive disease.

Multiple biological activities are the most prominent features of defibrinated sodium. In vitro and in vivo studies have shown that defibrinated sodium has anti-atherosclerosis, anti-inflammatory, anti-myocardial ischemia, fibrinolysis and anti-thrombotic activities. The anti-tumor application prospects of defibrinated sodium have recently attracted the attention of scholars. The detailed mechanism of action of defibrinated sodium has not yet been fully elucidated. On the one hand, it is related to the characteristics of the polyanion of defibrinated sodium. On the other hand, defibrinated sodium is a single-stranded deoxyoligonucleotide mixture, and there is complementary pairing of bases in its molecule, which forms the basis of DF sequence diversity and spatial conformation diversity. These are directly related to the biological activity diversity of defibrinated sodium. Defibrotide sodium has been confirmed to exert biological functions mainly by reacting with vascular endothelial cells. For example, defibrination sodium can increase the activity of fibrinolysis-related factors and inhibit the activity of coagulation-related factors. It has been confirmed in vitro that defibrination sodium is an agonist of plasmin and can increase the anticoagulant activity of heparin.

Defibrotide sodium (defibrinoside) was first approved for marketing by the EU EMA on October 18, 2013, and was officially approved by the US FDA on March 30, 2016. So far, the drug has not been approved for domestic marketing. However, patients are still very concerned about its price. So, how much does defibrinated sodium cost?

According to Medical Travel, the original drug is priced at 21,600$/box in foreign countries, and the specification is 200mg/box. Although this price is expensive, based on the actual situation of the current market, there are not many purchasing channels for patients to choose from, so patients can choose based on their own needs when making actual purchases.

Recommended hot articles: /newsDetail/78581.html