去纤维钠多久打一次？

(Defitelio) is an adenosine receptor agonist with multiple effects. The adenosine A1/A2 receptors of endothelial cells are involved in the regulation of endothelial cells and the response of endothelial cells to injury. The drug can act on these receptors to produce a variety of downstream effects. It can also reduce the expression of cell adhesion molecules on the surface of endothelial cells, thereby reducing the adhesion of leukocytes to vascular endothelial cells and reducing inflammatory damage to endothelial cells. In addition, DF can also promote the release of prostaglandin 12 (PGl2) and prostaglandin E2 (PGE2), thereby causing vasodilation, inhibiting platelet aggregation, and reducing ischemic damage.

In order to continue to benefit from it, it is important to master the correct method of medication. So, how often should you take defibrinated sodium?

The recommended dose of defibrotide sodium (Defibrotide) for adult and pediatric patients is 6.25 mg/kg given every 6 hours as a 2-hour intravenous infusion. The dose should be based on the patient's baseline weight, which is defined as the patient's weight before the HSCT preparation protocol. Give Defitelio for a minimum of 21 days. If signs and symptoms of hepatic VOD have not resolved after 21 days, continue defibrotide until resolution of VOD or up to a maximum of 60 days. Defibrotide must be diluted before infusion.

Before administering Defitelio, ensure that the patient has not experienced clinically significant bleeding and is hemodynamically stable on no more than one vasopressor. Defitelio was administered by constant intravenous infusion over a 2-hour period. Administer the diluted (Defitelio) solution using an infusion set equipped with a 0.2 micron in-line filter. Flush the intravenous administration line (peripheral or central) with 5% dextrose injection, USP, or 0.9% sodium chloride injection, USP, before and immediately after administration.

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