去纤维钠注射后多久见效？

(Defitelio) is a polydeoxynucleotide extracted from mammals. It is an agonist of adenosine receptors and has anti-thrombotic, anti-ischemic, anti-inflammatory and thrombolytic properties. It can increase the expression of thrombomodulin, stimulate fibrinolysis through the increase of t-PA function and the decrease of PAI-1 activity, and can increase the cure rate of VOD without obvious toxicity.

So, for patients, how long does it take for defibrinated sodium injection to take effect?

Since the actual progress of each patient's condition is different, and is affected by factors such as body constitution and nursing care, how long it takes for sodium defibrination to be effective after injection will vary from person to person. Typically, the minimum duration of treatment with Defitelio is 21 days. If a patient's signs and symptoms of hepatic veno-occlusive disease do not resolve after 21 days, treatment should be continued until benefit is no longer available.

The latest treatments related to Defitelio are: ①Defitelio plus N-acetylcysteine (NAC). There are related reports, continuous high-dose NAC 150 mg/kg, intravenous bolus, then 50 mg/kg/d and Defitelio 10-30 mg/kg/d combined treatment of VOD after HSCT has been successful; ② Defibrotide sodium plus AT-Ⅲ, for patients preparing for HSCT, defibrotide sodium (20-80 days) is given from pretreatment to +30 days after transplantation. mg/kg/d) combined with AT-Ⅲ can significantly reduce the incidence of severe VOD and related fatality rates; ③ Defibrotide sodium (i.e., defibrotide) plus protein C was used to treat 2 patients who developed severe VOD after BMT. The symptoms were significantly relieved after the addition of protein C, suggesting that protein C may play an auxiliary role in the treatment of VOD.

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