去纤苷注射方法

It is currently recognized as the most promising new drug for the treatment of hepatic veno-occlusive disease (HOVD) after hematopoietic stem cell transplantation (HSCT). So what is the injection method of defibrotide?

Injection method of defibrotide:

1. The recommended dose of defibrotide for adult and pediatric patients is 6.25 mg/kg given every 6 hours as a 2-hour intravenous infusion. The dose should be based on the patient's baseline weight, which is defined as the patient's weight before the HSCT preparation protocol.

2. Give defibrotide for a minimum of 21 days. If signs and symptoms of hepatic VOD have not resolved after 21 days, continue defibrotide until resolution of VOD or up to a maximum of 60 days.

3. Defibrotide must be diluted before infusion.

4. Before administration of defibrotide, confirm that the patient has not experienced clinically significant bleeding and is hemodynamically stable on no more than one vasopressor.

5. Administer defibrotide by constant intravenous infusion over a 2-hour period.

6. Administer the diluted defibrotide solution using an infusion set equipped with a 0.2 micron in-line filter. Flush the intravenous administration line (peripheral or central) with 5% Dextrose Injection, USP, or 0.9% Sodium Chloride Injection, USP, before and immediately after administration.

7. Do not co-administer defibrotide and other intravenous drugs in the same intravenous line at the same time.

In addition, patients should be cautioned that the pharmacodynamic activity of antithrombotic/fibrinolytic drugs such as heparin or alteplase may be enhanced. Concomitant use of defibrinoside with antithrombotic or fibrinolytic agents is contraindicated due to increased risk of bleeding. Do not initiate defibrotide in patients with active bleeding. Monitor patients for signs of bleeding. If a patient bleeds while taking defibrotide, discontinue defibrotide, treat the cause, and provide supportive care until bleeding has stopped.

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