爱尔兰爵士制药的去纤维钠怎么样？

For some patients with leukemia and lymphoma, hematopoietic stem transplantation (HSCT) is the disease and the only hope to regain health. Hepatic veno-occlusive disease (HVOD) is one of the serious complications after hematopoietic stem transplantation (HSCT), and the mortality rate of severe HVOD can be as high as 100%. (Defibrotide sodium, produced in Italy) is a mixture of single-stranded oligonucleotides with anti-thrombotic and fibrinolytic effects. In recent years, multiple research results have shown that defibrotide is safe and effective in preventing and treating HVOD.

An open-label, randomized phase III trial led by the University of Regensburg in Germany showed that defibrotide can reduce the risk of this disease. In this clinical trial, researchers recruited a total of 356 subjects during three years (2006.1.25-2009.1.29). The subjects were randomly assigned by computer into two groups: prevention group (intravenous administration) and control group (placebo). The results showed that the incidence of veno-occlusive disease in the prevention group within 30 days after hematopoietic stem cell transplantation was 12% (22/180), and that in the control group was 20% (35/176); the risk difference between the two groups was ?7.7%, Z test p=0.0488, the difference was statistically significant; at the same time, 87% (154/177) of the prevention group had side effects within 180 days after transplantation, compared with 20% (35/177) in the control group. 88% (155/176), no difference, indicated that the side effects were caused by blood stem cell transplantation or veno-occlusive disease, not fibrinide.

Therefore, fibrinide can reduce the risk of veno-occlusive disease after blood stem cell transplantation and is well tolerated. In addition, there are data indicating that fibrinic acid can reduce the rate of graft-versus-host reaction, making it a wise choice clinically.

Jazz Pharmaceuticals was founded in 2003 and is headquartered in Dublin, Ireland, with 885 full-time employees. It is a commercial-stage biopharmaceutical company engaged in the identification, development and commercialization of pharmaceutical products. According to Medical Companion Travel, the 200mg specification is around 21,600. Since exchange rates fluctuate and prices are not fixed, please consult Medical Travel for specific prices.