爱尔兰爵士制药的defiteli的作用及功效

Jazz Pharmaceuticals Public Limited Company (NASDAQ: JAZZ) was founded in 2003 and is headquartered in Dublin, Ireland. It has 1,620 full-time employees. It is a commercial-stage biopharmaceutical company. Defiteli is developed and produced by Jazz Pharmaceuticals in Ireland. What are the functions and efficacy of Jazz Pharmaceuticals in Ireland?

Preclinical studies have confirmed that Irish Jazz Pharmaceuticals' defiteli has anti-thrombotic, fibrinolytic, anti-ischemic and anti-infective effects in vivo and in vitro. Defibrotide sodium is an adenosine receptor agonist with multiple effects. The adenosine A1/A2 receptors of endothelial cells are involved in the regulation of endothelial cells and the response of endothelial cells to injury. Defibrotide (defiteli) can act on these receptors to produce a variety of downstream effects. Defibrinated sodium can also reduce the expression of cell adhesion molecules on the surface of endothelial cells, thereby reducing the adhesion of leukocytes to vascular endothelial cells and reducing the inflammatory damage of endothelial cells.

A Phase 2 trial of 75 patients, a Phase 3 trial of 102 patients and an expansion trial of an additional 351 patients analyzed Jazz Pharmaceuticals' effects. All patients in the trial were diagnosed with hepatic veno-occlusive disease and associated renal or pulmonary dysfunction after HSCT. In the phase 2 trial, 44% of patients survived 100 days after transplantation, compared with 38% in the phase 3 trial and 45% in the expanded trial. The most common adverse reactions included hypotension, diarrhea, vomiting, nausea, and epistaxis.

Recommended hot articles:

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.