去纤苷是冷链药吗？

It is suitable for the treatment of adults and children with hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), and renal or pulmonary dysfunction after hematopoietic stem cell transplantation (HSCT).

Mechanism of action of defibrotide sodium (defibrinoside): In vitro, defibrotide sodium enhances the enzymatic activity of plasmin, which hydrolyzes fibrin clots. Studies evaluating the pharmacological effects of defibrinated sodium on endothelial cells (ECs) have been primarily conducted in human microvascular endothelial cell lines. In vitro, defibrotide increases tissue plasminogen activator (t-PA) and thrombomodulin expression and decreases von Willebrand factor (vWF) and plasminogen activator inhibitor-1 (PAI-1) expression, thereby reducing EC activation and increasing EC-mediated fibrinolysis. Defibrinated sodium protects ECs from chemotherapy, tumor necrosis factor-α (TNF-α), serum starvation, and perfusion-induced injury.

Cold chain refers to a special supply chain system in which certain food raw materials, processed foods or semi-finished products, special biological products and drugs are purchased, processed and inactivated. During product processing, storage, transportation, distribution and retail, and use, all links are always in the specific low-temperature environment necessary for the product to reduce losses, prevent contamination and deterioration, and ensure product food safety, biological safety, and drug safety. Drug storage has a certain impact on drug efficacy, so is defibrotide a cold chain drug?

Not a cold chain drug, defibrotide is stored at 20°C-25°C (68°F-77°F); excursions allowed between 15°C and 30°C (59°F and 86°F). Just store at room temperature.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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