爱尔兰爵士制药的去纤苷用途和效果

Purpose of Irish Jazz Pharmaceuticals: Defibrinoside from Irish Jazz Pharmaceuticals is a single-stranded oligonucleotide mixture with anti-thrombotic and fibrinolytic effects. It is suitable for patients with hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS).

Jazz Pharmaceuticals Public Limited Company (NASDAQ: JAZZ) was founded in 2003 and is headquartered in Dublin, Ireland. It has 1,620 full-time employees. It is a commercial-stage biopharmaceutical company. How effective is Jazz Pharmaceuticals' defibrinoside?

In a phase 2 trial of 75 patients, a phase 3 trial of 102 patients, and an expansion trial of an additional 351 patients, all patients in the trial were diagnosed with hepatic VOD with renal or pulmonary dysfunction after HSCT. In the phase 2 trial, 44% of patients survived 100 days after transplantation, compared with 38% in the phase 3 trial and 45% in the expanded trial, and the FDA noted in a report that the expected 100-day survival rate for patients with severe hepatic VOD who were not treated with defibrotide (desoside) was 21%-31%. Hypersensitivity reactions have occurred in less than 2% of patients treated with defibrotide. These reactions include rash, urticaria, and angioedema. Especially if there is a history of previous exposure. If a severe hypersensitivity reaction occurs, discontinue defibrination, treat with standard medical care, and monitor until symptoms resolve.

In addition, defibrinated sodium () also has a certain therapeutic effect on multiple myeloma. It has achieved good results in the treatment of multiple myeloma and hepatic veno-occlusive disease caused by chemotherapy and stem cell transplantation, meeting the treatment needs of this rare and fatal disease. For more information about Irish Jazz Pharmaceuticals’ defibrotide, you can contact customer service for consultation.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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