【关注】去纤苷（Defibrotide）的治疗效果及不良反应

Defibrotide is the first drug approved by the US FDA to treat severe hepatic veno-occlusive disease. The drug has anti-thrombotic, fibrinolytic, anti-ischemic and anti-infective effects in vivo and in vitro. Patients who need to be treated with drugs are very concerned about its therapeutic effects, so today we will learn in detail about the effects and possible adverse reactions that may occur when receiving this drug.

In a phase III, multi-center, randomized clinical trial completed in Europe, a total of 356 stem cell transplant patients were recruited to compare the incidence of hepatic vein occlusion 30 days after transplantation. Hepatic vein occlusion occurred in 2 of 180 patients in the Defibrotide group, accounting for 12%; in the control group, 35 of 176 patients developed hepatic vein occlusion, accounting for 20%.

In a clinical trial on the treatment of HVOD in children, the complete response (CR) rate of patients treated with defibrotide was 76%, and the overall survival rate 100 days after transplantation was 64%. It can be seen from the above two trials that defibrotide has a significant effect in treating hepatic veno-occlusive disease. It can prolong the survival period of patients, increase the remission rate and overall survival rate, improve the quality of life of patients, and has a positive effect on the patient's condition. However, patients should not blindly use this drug for treatment, as defibrotide treatment will also produce some adverse reactions.

Adverse reactions of defibrotide

Adverse reactions of Defibrotide include: hypotension, diarrhea, vomiting, nausea, nose bleeding, allergic reactions, etc. Due to individual differences, each patient will have different side effects and the timing of side effects after receiving this drug. If a patient has a serious adverse reaction during Defibrotide treatment, he should go to the hospital immediately and the doctor will adjust the medication plan. Patients are not allowed to use other drugs without authorization.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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