预防静脉血栓形成药-去纤苷

Defibrotide is derived from porcine mucosa and bovine lung. It was approved for marketing by the EU EMA on October 18, 2013, and was designated as an orphan drug. On March 30, 2016, defibrotide was approved by the US FDA to treat adult and pediatric patients with hepatic venule occlusion and renal or pulmonary abnormalities after blood or bone marrow hematopoietic stem cell transplantation, and was granted priority review and orphan drug status. It is the first drug approved by the FDA to treat severe hepatic venule occlusion.

In vitro, defibrinoside can enhance the activity of plasmin to hydrolyze fibrin clots; defibrinoside can up-regulate the expression of tissue plasminogen activator and thromboplastin regulatory protein, while down-regulating the expression of von Willebrand factor and plasminogen activator inhibitor-1, thereby reducing endothelial cell activation and increasing endothelial cell-mediated fibrinolysis; defibrinoside can protect endothelial cells from damage caused by chemotherapy, TNFα, serum starvation and reperfusion.

A phase III clinical trial study pointed out that after hematopoietic stem cell transplantation, patients with severe hepatic venule occlusion and organ failure received intravenous injection of defibrinoside 6.25 mg/kg every 6 hours. After 100 days, the complete remission rate was significantly improved and the mortality rate was significantly reduced.

For nausea, hypotension, vomiting, allergic reactions, diarrhea, nosebleeds, etc. Finally, the editor of Medical Companion Travel would like to solemnly tell everyone that if patients are currently using the drug defibrotide, they must remember the doctor's instructions and take the medicine according to the doctor's instructions. Some patients think that taking more medicine can improve the effect of the medicine, and some patients cannot tolerate the side effects and reduce the dose. These behaviors are not conducive to drug treatment. Only by carefully following the doctor's instructions can the effect of the drug itself be maximized.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.