爱尔兰爵士制药的去纤维钠有什么副作用？

Side effects: In clinical trials, the most common adverse reactions (incidence ≥10% and independent causal relationship) of defibrotide were hypotension, diarrhea, vomiting, nausea, and epistaxis. The most common serious adverse reactions (incidence ≥5% and independent causal relationship) were hypotension (11%) and alveolar hemorrhage (7%). Bleeding events of any type and any grade were reported in 104 (59%) patients, and in 35 (20%) the events were grade 4-5.

Hypersensitivity reactions have occurred in less than 2% of patients treated with defibrotide. These reactions include rash, urticaria, and angioedema. One case of allergic reaction was reported in a patient who had previously received defibrotide. Monitor patients for hypersensitivity reactions. Especially if there is a history of previous exposure. If a severe hypersensitivity reaction occurs, discontinue defibrotide, treat with standard medical care, and monitor until symptoms resolve.

The recommended dose of defibrotide sodium is 6.25 mg/kg given as a 2-hour intravenous infusion every 6 hours. The dose should be based on the patient's baseline weight, which is defined as the patient's weight before the HSCT (hematopoietic stem cell transplant) preparation protocol. Defibrotide was administered for a minimum of 21 days. If signs and symptoms of hepatic veno-occlusive disease have not resolved after 21 days, continue defibrotide until resolution of hepatic veno-occlusive disease or for a maximum of 60 days.

Jazz Pharmaceuticals was founded in 2003 and is headquartered in Dublin, Ireland, with 885 full-time employees. It is a commercial-stage biopharmaceutical company engaged in the identification, development and commercialization of pharmaceutical products. According to Medical Companion Travel, the 200mg specification is around 21,600. Since exchange rates fluctuate and prices are not fixed, please consult Medical Travel for details.