去纤苷在中国上市了吗?好购买吗？

Introduction: Defibrotide is a mixture of single-stranded oligonucleotides purified from porcine intestinal mucosa. It is used to treat hepatic veno-occlusive disease in humans undergoing bone marrow transplantation. It has different restrictions in the United States and the European Union. Defibrotide works by protecting the cells lining blood vessels in the liver and preventing blood clotting, in a manner that is not yet understood.

The marketing status of defibrotide in China

As of August 2, 2024, it has not been approved for marketing in China and cannot be purchased directly in China for the time being. However, defibrotide has been launched in Japan, the United States and other countries. The trade name of defibrinoside is Defitelio, a drug used to treat severe hepatic veno-occlusive disease (VOD). It has obtained marketing approval in many countries such as Europe and the United States, and is included in the World Essential Medicines List of the World Health Organization (WHO).

On March 30, 2016, the U.S. Food and Drug Administration approved defibrotide for the treatment of adult and pediatric patients with hepatic veno-occlusive disease (VOD, also known as sinusoidal obstruction syndrome) who develop renal or pulmonary dysfunction after hematopoietic stem cell transplantation (HSCT).

Purchase channels of defibrotide

1. Hospital or pharmacy: Patients can go to the country where defibrotide is listed and purchase defibrotide in the local hospital pharmacy or drug store. Patients can go directly to the hospital pharmacy for consultation and purchase. Usually, the pharmacies of large hospitals will stock defibrinoside. In some professional pharmacies or chain pharmacies, patients can also purchase defibrotide, but it is recommended to confirm the inventory by calling before purchasing.

2. Online pharmacies: Some drug sales websites on the Internet provide purchase services for defibrinoside, and some also provide door-to-door delivery services. However, when choosing online pharmacies to purchase medicines, you need to pay attention to choosing regular and reputable medicines, and carefully check the product details and instructions to ensure that you purchase regular and approved medicines.

3. Medical service institutions: Since defibrotide is not yet on the market in China, patients can also purchase it through medical service institutions. After placing the order, they usually get the drug by mail.

Dosage of defibrotide

The recommended dose and regimen mentioned is 6.25 mg/kg intravenously every 6 hours and infused every 2 hours for at least 21 days until VOD subsides or treatment lasts for up to 60 days.