去纤苷导致的不良反应怎么治疗？

Introduction: Defitelio, also known as Defitelio, is a drug used to treat hepatic veno-occlusive disease, a disease in which small veins in the liver become blocked, in adults and children with kidney or lung disease after receiving a stem cell transplant. Defibrotide may affect the cells lining blood vessels and may help improve blood flow in the liver.

Adverse reactions of defibrinoside

1. Hypotension: Use may cause blood pressure to drop and requires close monitoring.

2. Diarrhea, vomiting, and nausea: These gastrointestinal reactions are common adverse reactions in defibrotide treatment.

3. Epistaxis: Due to the anticoagulant effect of defibrotide, it may increase the risk of bleeding, including epistaxis.

4. Abnormal liver function and renal insufficiency: Although defibrotide is used to treat liver disease, in some cases, it may cause further damage to liver function or renal insufficiency.

5. Allergic reaction: It may manifest as rash, itching, urticaria, etc. In severe cases, anaphylactic shock may even occur.

6. Other adverse reactions: including alveolar hemorrhage, gastrointestinal bleeding, sepsis, graft-versus-host disease, pneumonia, pulmonary hemorrhage, intracranial hemorrhage, excess uric acid, cerebral hemorrhage, etc. These are the same, but the incidence is low.

Measures to deal with the adverse reactions of defibrotide

1. Hypotension: Patients can control their diet, avoid overeating at each meal, and supplement more protein-rich foods, such as lean meat, eggs, and milk. At the same time, they can appropriately strengthen exercise, improve physical fitness, and improve the regulatory function of nerves and blood vessels.

2. Diarrhea: Drink more water during diarrhea to avoid dehydration. You can also choose oral rehydration salt solution. Eat small and frequent meals, choose foods that are easy to digest, low in fat and low in fiber, and avoid irritating foods. If diarrhea symptoms are severe, over-the-counter antidiarrheal medications, such as montmorillonite powder, can be used to control symptoms.

3. Vomiting: When vomiting is obvious, you should fast temporarily, and then you can try to eat every 2-3 hours. If you need to replenish water, you can drink some warm water every 15-30 minutes. If vomiting symptoms persist, anti-emetic drugs, such as metoclopramide, can be used as directed by your doctor.

4. Nausea: Drinking warm water or lemon water can help relieve the symptoms of nausea, and avoid drinking drinks containing caffeine. Adjust your diet, choose light, easy-to-digest, and nutritious foods, avoid overeating, and chew carefully and slowly.

5. Nose bleeding: Compression is required to stop bleeding. For unilateral nose bleeding, you can compress the nose on the bleeding side, or you can apply a cold towel on the bridge of the nose to help stop bleeding. Under the guidance of a doctor, you can take hemostatic drugs such as vitamin K1 tablets or ethylamine tablets for treatment.

6. Bleeding from other parts of the body: Defibrotide treatment should be stopped immediately, the underlying cause should be treated, and supportive treatment should be provided until the bleeding stops.