去纤苷有几种规格?多少钱?

Introduction: Defitelio is a specific drug for the treatment of hepatic veno-occlusive disease. Its specification selection and medication safety are crucial to clinical treatment. This article will systematically introduce the specifications, price information and key precautions of this drug, providing a practical reference for medical professionals and patients.

Defibroside is available in several specifications

It is an intravenous injection drug. Its specifications are designed taking into account the convenience of clinical use and the need for precise dosing. Currently, there is only one standard specification available in the global market.

Standard Specifications

Defitelio produced by Irish Jazz Pharmaceuticals adopts a single-bottle specification of 200mg/2.5mL (80mg/mL). This concentration design facilitates accurate calculation of dosage based on patient weight.

Packaging specifications

Medicines are sold in boxes. Each box contains several 200mg/2.5mL injections. The specific number may vary depending on national and regional regulations. A common number is 10 per box.

No other specifications

Currently there are no products with other concentrations or packaging specifications on the market. Clinical use requires dilution or adjustment of the infusion rate to achieve individualized dosing.

When receiving medicines, medical personnel should check the consistency of packaging specifications and prescription requirements to ensure that the dosage is accurate.

How much does defibrotide cost in different specifications?

As an orphan drug, defibrotide’s pricing strategy reflects the characteristics of research and development costs and market demand. Understanding price information can help medical institutions manage drug budgets.

Single box pricing

The standard 200mg/2.5mL specification of Defitelio is priced at approximately US$5,310 per box in the US market. Prices may fluctuate slightly due to purchasing channels and regional policies.

Cost of treatment course

Based on the recommended dose of 6.25mg/kg every 6 hours, an adult of 60kg needs about 7.5 pills per day, and the total cost of a 21-day treatment course is about US$80,000-100,000.

Price structure

The high price is mainly due to large R&D investment and rare indications. Some national health insurance systems or charitable programs may provide cost support.

Medical institutions should purchase through formal channels and pay attention to possible policy changes and price adjustment information.

Precautions for defibrotide

Correctly understanding the risks of defibrotide medication is crucial to ensuring patient safety. Special attention should be paid to the following key issues during clinical use.

Bleeding risk management

This drug may increase fibrinolytic activity, and hematopoietic stem cell transplant patients have a higher risk of bleeding. Coagulation function needs to be assessed before medication, and signs of bleeding should be closely monitored during treatment.

Hypersensitivity reaction prevention

About 2% of patients may experience allergic reactions. Before first use, detailed inquiries about allergy history should be made, emergency equipment should be prepared, and the patient's reaction should be closely observed during the infusion process.

Usage for special groups

People with liver and kidney dysfunction usually do not need to adjust the dose, but need to strengthen monitoring. The pros and cons of use during pregnancy must be fully weighed, and breastfeeding should be suspended during lactation.

The medical team should establish an emergency plan to ensure that appropriate intervention measures can be taken in a timely manner if adverse reactions occur.