去纤苷一次能囤几盒?多少钱?

Defitelio is clinically used to treat adult and pediatric patients with hepatic veno-occlusive disease (VOD, also known as hepatic sinusoidal obstruction syndrome) and accompanying renal or pulmonary dysfunction after hematopoietic stem cell transplantation (HSCT). It can significantly improve the survival rate of patients, and its purchase quantity restrictions and medication specifications for special groups are of great significance to clinical treatment. This article will detail the purchase restrictions, price information, and medication guidance for special groups.

How many boxes of defibrinoside can be stored at a time

is a prescription. The purchase quantity of drugs is strictly controlled. Understanding the relevant regulations will help patients plan their medication plans reasonably.

Hospital Procurement Restrictions

Qualified hospitals usually purchase drugs on demand based on the number of patients. A single purchase does not exceed 3 months' dosage. Under special circumstances, it can be used. Apply for temporary incremental purchase.

Purchase restrictions for patients

When purchasing with a prescription, the amount of a single prescription is usually controlled within 7-14 days. Under special circumstances, it can be appropriately increased with the approval of the hospital's Pharmacy Committee.

Drug storage requirements

Unopened medicines need to be refrigerated at 2-8°C. They can only be stored at room temperature for 24 hours after opening, which limits the feasibility of stocking up in large quantities.

Patients should follow the doctor’s instructions and purchase according to the course of treatment to avoid drug failure or waste due to improper storage.

The high price of defitelioside is directly related to its orphan drug status. Understanding the price structure will help you plan your treatment budget.

International market price

Defitelio produced by Irish Jazz Pharmaceuticals is priced at approximately US$5,310 per box (200mg/2.5). mL), the price may fluctuate by 5%-10% due to differences in tax policies in different countries.

Treatment cost calculation

The standard regimen (6.25mg/kg every 6 hours) requires approximately 63 tubes for a 60kg adult, with a total cost of approximately US$160,000-180,000. .

Cost support policy

Some countries’ medical insurance covers part of the cost, and pharmaceutical companies may provide assistance programs. Domestic patients currently need to pay the full price themselves.

Before purchasing drugs, you should confirm the latest price information and understand possible cost reduction channels.

Medication of defibrotide in special populations

Different populations have different metabolism and tolerance of defibrotide, and individualized medication plans need to be developed.

Pregnant women

Animal experiments have shown embryotoxicity, which may be Can cause miscarriage. It is contraindicated during pregnancy. Pregnancy status must be confirmed before taking the drug, and reliable contraceptive measures should be taken during treatment.

Lactating women

Due to the lack of human data, it is recommended to suspend breastfeeding during treatment.

Pediatric patients can resume breastfeeding after 5 half-lives (about 10 hours).

It is safe and effective in children over 1 month old. The dosage needs to be adjusted according to body weight. Long-term use requires monitoring of growth and development, especially in adolescent patients.

Clinical data are limited. It is recommended to start with a low dose and pay special attention to drug interactions.

Renal insufficiency

Exposure in patients with severe renal impairment increases by 50%-60%, but there is no need to adjust the dose. Hemodialysis does not affect the efficacy of the drug and can be administered according to the conventional regimen.

Specialized patients need to assess the benefit-risk ratio, develop individualized treatment plans and strengthen medication monitoring.