奥贝胆酸的用法和用量

Recommended dosage of Obetix: Oral tablets, the initial recommended dose is 5 mg once daily. Based on clinical response, treatment is gradually titrated to 10 mg (once daily) over 6 months. Obeticholic acid needs to be taken under the guidance of an experienced expert.

Obeticholic acid is a farnesoid X receptor agonist, which indirectly inhibits the gene expression of cytochrome 7A1 (CYP7A1) by activating the farnesoid X receptor. Since CYP7A1 is the rate-limiting enzyme in cholic acid biosynthesis, obeticholic acid can inhibit cholic acid synthesis and be used to treat primary biliary cirrhosis and non-alcoholic fatty liver disease.

Obeticholic acid is approved in combination with ursodeoxycholic acid (UDCA) in adults with primary biliary cholangitis (formerly known as primary biliary cirrhosis, PBC) who have an inadequate response to UDCA, or as monotherapy in adults with primary biliary cholangitis who are intolerant to UDCA.