Desirox说明书

Instructions

Generic name: Deferasirox

Product name: Enrig

Full names: Deferasirox, Enrig, Deferasirox, Desirox

Indications:

It is used to treat chronic iron overload in patients with β-thalassemia older than 6 years old due to frequent blood transfusions (monthly administration of concentrated red blood cells ≥7mL/kg);

For children under 6 years old and iron overload caused by other transfusion-dependent diseases, the safety and effectiveness data of Enrig in Chinese patients are limited, and it is recommended to use it with caution based on the specific conditions of the patients.

Adverse reactions:

>10%: Increased serum creatinine (dose related; 7-38%) Abdominal pain (21-28%) Nausea (11-23%) Vomiting (10-21%) Diarrhea (12-20%) Proteinuria (19%) Irritability (19%) Headache (16%) Cough (14%) Nasopharyngitis (13%) Throat pain (11%) Influenza (11%) Rash (8-11%)

1-10%: Respiratory tract infection (10%) Bronchitis (9%) Increased ALT (2-8%) Arthralgia, back pain (6-7%) Acute tonsillitis (6%) Rhinitis (6%) Fatigue (6%) Ear infection (5%) Transaminases (4%) Urticaria (4%)

<1%: Anaphylaxis, angioedema, cytopenias including agranulocytosis, neutropenia, and thrombocytopenia; leukocytoclastic vasculitis

Things to note:

1. Allergy

2. Estimated GFR<40ml/min/1.73m² or serum creatinine>2 x ULN

3. Poor performance status and high-risk myelodysplastic syndrome or advanced malignancy

4. Platelet count <50 x10 ⁹ / L

Storage:

Should be kept at room temperature 25°C (77°F); short trips allowed 15-30°C (59-86°F)