恩瑞格用量多少呢？

It was approved by the European Commission in December 2012 for the treatment of chronic iron overload in patients aged 10 years and above with non-transfusion-dependent thalassemia (NTDT) syndrome who require chelation therapy due to contraindications or insufficiency of deferoxamine mesylate therapy. On January 23, 2013, the FDA approved the new indication of Enriga for the treatment of chronic iron overload in patients with non-transfusion-dependent thalassemia (NTDT) aged 10 years and above. Today let’s take a look at how much Enrig is used?

Enrig Indications 1. Patients with chronic iron overload and transfusion hemosiderinosis secondary to blood transfusion who are 2 years old or older will have symptoms of chronic iron overload when serum ferritin continues to be >1000 L. At this time, iron chelation therapy should be started. 2. Iron chelators can also be given to patients undergoing ASCT treatment when iron overload occurs; 3. It can be used to treat reversible renal insufficiency caused by Fanconi syndrome.

Starting dose: The recommended starting daily dose of Enrig is 20 mg/kg. For patients who receive monthly transfusions of more than 14 mL/kg of packed red blood cells (i.e., more than 4 units/month in adults) and who need to reduce excess iron exposure, a starting dose of 30 mg/kg/day may be considered. For patients who receive monthly transfusions of less than 7 mL/kg of packed red blood cells (i.e., less than 2 units/month in adults) and who need to maintain body iron balance, a starting dose of 10 mg/kg/day may be considered. In patients who have already responded well to deferoxamine therapy, an initial dose of Enriga equivalent to half the deferoxamine dose may be considered. (For example, a patient receiving deferoxamine 40 mg/kg/day, 5 days a week or equivalent, may start with 20 mg/kg if switched to Enriga.)

How to take: Enrige should be taken on an empty stomach at least 30 minutes before meals, once a day, preferably at the same time every day. Tablets should not be chewed or swallowed whole. Enrig should not be taken with aluminum-containing antacids. The dosage (mg/kg) needs to be calculated and rounded to the nearest whole tablet. Completely dissolve the tablets in water, apple juice or orange juice (100-200mL) by stirring until a clear suspension is obtained and then drink it. The remaining medicine must be added with a small amount of water, apple juice or orange juice and mixed well before taking. Not recommended for dissolution in carbonated drinks or milk as it can cause foaming and slow dispersion.

The above is the content of the dosage, I hope it can help you!