恩瑞格作用效果

In 2010, dispersible tablets were approved for marketing in China, and were approved for the treatment of chronic iron overload caused by frequent blood transfusions in beta-thalassemia patients aged 2 years and above and chronic iron overload in patients with non-transfusion-dependent thalassemia (NTDT) syndrome aged 10 years and above.

Enrig’s effects:

Enrig can remove free iron and intracellular iron, prevent myocardial cells from taking up iron, and directly remove excess iron from myocardial cells, resulting in a continuous reduction of non-transferrin in plasma. It is a first-line drug for patients with chronic iron overload caused by blood transfusion.

Enrige dispersible tablets can be taken orally once a day, with good patient compliance, ensuring long-term iron removal treatment. The above-mentioned good iron-removing effectiveness, safety and patient compliance of Enrig have greatly reduced the mortality rate of patients with diseases such as thalassemia and MDS that require long-term blood transfusion treatment, and improved their quality of life.

Enrego is a tridentate iron chelator that combines with ferric ions in a 2:1 ratio to form a complex that is excreted in the feces, thereby reducing iron storage in the body. Due to the continuous presence of Enrig in the plasma, plasma non-transferrin-bound iron can be continuously reduced, directly removing the iron formed by toxicity in the body.

Blood transfusion is the mainstay of treatment for thalassemia major and intermedia. In addition, blood transfusion is also the main maintenance therapy for myelodysplastic syndrome (MDS). There are about 300,000 new MDS patients in my country every year. Long-term blood transfusion can easily lead to secondary iron overload. Iron overload refers to the pathological phenomenon of excessive iron deposition in human tissues and organs, leading to cell damage and organ dysfunction. Iron overload can cause damage to cardiovascular, endocrine, liver, kidney, nervous system, etc., leading to various diseases and serious harm.

Iron chelators can effectively increase iron excretion, reduce iron content in the body and its pathological deposition in various organs. They are currently the only effective drugs for the treatment of iron overload.