地拉罗司适用于什么病症？

(Deferasirox) is a tridentate iron chelator that combines with ferric ions to form a complex in a ratio of 2:1. So, what diseases is Deferasirox suitable for?

Indications for Deferasirox:

1. Deferasirox can be used to treat reversible renal insufficiency caused by Fanconi syndrome.

2. For the treatment of secondary hemochromatosis.

3. Can be used to treat porphyria cutaneous tarda.

4. For the treatment of myelodysplastic syndrome.

5. Used to treat iron overload caused by blood transfusion in patients with chronic anemia 2 years old and above.

Pharmacological effects of deferasirox:

Deferasirox has pharmacological effects such as antifungal effects (such as Mucor mold growing in an iron-rich environment), anti-cell proliferation, anti-malaria, anti-oxidative stress damage, and anti-cytotoxicity-induced apoptosis.

1. Deferasirox and fungal infections

Iron is a substance that fungi rely on for survival, and it plays a very important role in the growth and toxicity of fungi. The antifungal effect of iron chelators may lie in their removal of iron necessary for fungal growth, thereby achieving the purpose of treating fungal infections.

2. Deferasirox and cell proliferation

Iron plays a very important role in the process of cell proliferation, and iron chelators may have anti-cell proliferation properties. This suggests that iron chelators may become a new type of anti-cancer agent for the treatment of tumors.

Pharmacokinetics of deferasirox:

Deferasirox is excreted in the feces after taking it, thereby reducing iron stores in the body. Due to the continued presence of deferasirox in plasma, plasma non-transferrin-bound iron can be continuously reduced and the iron formed by toxicity in the body can be directly removed.

The main metabolic pathway is through glucuronidation to generate the metabolite products M3 (acyl glucuronide) and M6 (2-O-glucuronide).