Desirox适用于什么病症？

In 2010, it was approved for marketing in China. So, what diseases is Desirox suitable for?

Indications of Desirox:

1. Desirox can be used to treat reversible renal insufficiency caused by Fanconi syndrome.

2. For the treatment of secondary hemochromatosis.

3. Can be used to treat porphyria cutaneous tarda.

4. For the treatment of myelodysplastic syndrome.

5. Used to treat iron overload caused by blood transfusion in patients with chronic anemia 2 years old and above.

Desirox usage and dosage:

It is recommended that patients with iron accumulation, such as those who require long-term blood transfusion (blood transfusion volume up to 100 ml/kg) and whose serum ferritin exceeds 1000 μg/L, are initially recommended to take deferasirox at a dose of 20 mg/kg daily depending on their body weight. Depending on the improvement of serum ferritin indicators, patients may need to adjust or increase the dose of deferasirox. Generally, the dose will be increased in units of 5 mg/kg or 10 mg/kg, but the total dose should not exceed 30 mg/kg per day.

Pharmacological effects of Desirox:

Desirox has pharmacological effects such as antifungal effects (such as Mucor mold that grows in iron-rich environments), anti-cell proliferation, anti-malarial, anti-oxidative stress damage, and anti-cytotoxicity-induced apoptosis.

1. Desirox and Fungal Infections Iron is a substance that fungi rely on for survival. It plays a very important role in the growth and toxicity of fungi. The antifungal effect of iron chelators may lie in their removal of iron necessary for fungal growth, thereby achieving the purpose of treating fungal infections.

2. Cell proliferation. Iron plays a very important role in the process of cell proliferation, and iron chelators may have anti-cell proliferation properties. This suggests that iron chelators may become a new type of anti-cancer agent for the treatment of tumors.