Deferasirox推荐用量多少呢？

Iron chelators can effectively increase iron excretion, reduce iron content in the body and its pathological deposition in various organs. They are currently the only effective drugs for the treatment of iron overload.

So, what is the recommended dosage of Deferasirox?

Recommended dosage of Deferasirox:

(1) After receiving 10 to 20 blood transfusion treatments. The common dose of Deferasirox is 20 mg/(kg·d); if the child has a high iron load, the dose is 30 mg/(kg·d); if the child has a low iron load, the dose is 10 to 15 mg/(kg·d).

Special attention: a foreign prospective controlled study. Comparing the treatment of 296 children with thalassemia major taking Deferasirox and 290 cases of deferoxamine. It was found that the oral dose of Deferasirox 20 mg/(kg·d) can maintain serum ferritin at 2000ug/L; if the oral dose of Deferasirox is 30 mg/(kg·d), the serum ferritin will decrease by an average of 1249ug/L per year. Apply LIC to analyze iron loading status. It was found that oral Deferasirox 20 mg/(kg·d) can effectively achieve iron balance in the body, while the dose of 30 mg/(kg·d) can achieve the purpose of reducing iron accumulation in the body, while the dose of 10 mg/(kg·d) is not enough to reduce iron accumulation in the body and causes a slow increase in iron accumulation.

Suitable for children over 2 years old, take once a day before meals.

In addition, in order to ensure better efficacy, combination with strong inducers of UDP-glucuronosyltransferase (UGT) (such as rifampicin, phenytoin, sedatives and hypnotics, protease inhibitors) and cholestyramine should be avoided. Do not administer concurrently with aluminum-containing antacids. Not to be combined with other iron chelation treatments. Be careful with repaglinide, drugs with potential ulcerogenic effects such as NSAIDs, cortisones, or oral bisphosphonates, drugs metabolized by CYP3A4 (such as cyclosporine, simvastatin, hormonal contraceptives). Withhold Deferasirox at least 5 days before performing gallium-67 imaging.