Deferasirox治疗铁质积聚的效果如何呢？

It is used to treat chronic iron overload in patients with β-thalassemia who are older than 6 years old due to frequent blood transfusions (monthly administration of concentrated red blood cells ≥7mL/kg); for children under 6 years old and patients with iron overload caused by other transfusion-dependent diseases.

So, how effective is Deferasirox in treating iron buildup?

Therapeutic benefits of Deferasirox for treating iron accumulation:

To evaluate the efficacy and safety of Deferasirox, a new oral iron chelator, in the treatment of iron overload in patients with β-thalassemia major (β-thalassaemia).

A single-group, open trial design was used to observe the efficacy and safety of Deferasirox in 23 patients with severe β-thalassemia iron overload during a 3-year follow-up.

Results: None of the 23 patients with severe β-thalassaemia used iron chelators regularly before treatment, and the iron overload condition was severe [the average baseline value of serum ferritin was (5433.96±2873.90) μg/L]. Deferasirox at 20 mg·kg-1·d-1 could maintain the patient's iron overload in a balanced state, and there was no significant change in serum ferritin levels before and after treatment; with the extension of treatment time, the dosage increased, ≥30 mg·kg-1·d-1 of Deferasirox can bring patients' iron overload to a negative balance state, and the difference in serum ferritin levels before and after treatment is statistically significant (P<0.01).

There were no serious adverse reactions to Deferasirox during the 3-year follow-up. Common adverse reactions were mild increases in liver transaminases and serum creatinine. All 23 patients were able to take the medicine on time and successfully completed the clinical study, with no deaths.

Conclusion: As a new type of oral iron chelator, it can significantly improve the iron overload condition of patients, and its efficacy is related to treatment time and drug dosage. With its simple medication method, good safety and tolerability, Deferasirox can significantly improve patients’ quality of life and better meet the treatment needs of patients with iron overload.