地拉罗司的用法和用量

For the treatment of chronic iron overload caused by frequent blood transfusions (monthly administration of concentrated red blood cells ≥7mL/kg) in patients with β-thalassemia older than 6 years old;

For iron overload caused by children under 6 years old and other transfusion-dependent diseases, Enrig's safety and effectiveness data for Chinese patients are limited. It is recommended to use it with caution based on the specific situation of the patient. So, what is the usage and dosage of deferasirox?

How to use deferasirox and dosage:

The recommended starting daily dose of deferasirox is 20 mg/kg.

For patients who receive monthly transfusions of more than 14 mL/kg of packed red blood cells (ie, more than 4 units/month in adults) and who need to reduce excess iron exposure, a starting dose of 30 mg/kg/day may be considered.

For patients who receive monthly transfusions of less than 7 mL/kg of packed red blood cells (i.e., less than 2 units/month in adults) and who need to maintain body iron balance, a starting dose of 10 mg/kg/day may be considered.

In patients who have already responded well to deferoxamine therapy, an initial dose equivalent to half the deferoxamine dose may be considered. Take it on an empty stomach at least 30 minutes before meals, once a day, preferably at the same time every day.

Deferasirox dose adjustment:

Myelosuppression: Interrupt treatment; may restart once cause of cytopenia is determined;

Disabled if platelet count <50,000/mm3;

Cutaneous Toxicity: Rash (Severe): Interrupt treatment; may be reintroduced at lower doses (with future dose escalations) and oral corticosteroids for a short period of time.

Serious skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme): Stop and evaluate.

Gastrointestinal: Discontinue treatment for suspected gastrointestinal ulceration or bleeding.

Hearing loss or visual impairment: Consider dose reduction or treatment interruption.

Common adverse reactions of deferasirox: diarrhea, vomiting, headache, abdominal pain, fever, rash, increased serum creatinine (Creatinine), etc.

Other adverse reactions: increased liver enzymes, cough, throat inflammation, urticaria.