用地拉罗司需要注意什么事项呢？

It is used to treat chronic iron overload in beta-thalassemia patients older than 6 years old due to frequent blood transfusions. It has the advantage of good treatment compliance. So, what should we pay attention to when using deferasirox?

1. Patients should take it 30 minutes before meals. Take deferasirox at the same time each day.

2. Auditory interference: Hearing loss and high-frequency hearing loss have been reported (rarely) with use; perform an auditory test before starting and at regular intervals (every 12 months) during use; if abnormalities occur, monitor closely and consider dose reduction or treatment interruption.

3. Skin toxicity: May cause rash (dose related); mild to moderate rash may resolve without interrupting treatment; for severe rash, interrupt and consider restarting with dose escalation and lower doses of oral steroids.

4. Serious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, and erythema multiforme have also been reported; the risk of other skin reactions including drug reactions with eosinophilia and systemic symptoms cannot be excluded.

Myelosuppression: Cytopenia (including agranulocytosis, neutropenia, thrombocytopenia, and worsening anemia) (some fatal) has been reported; patients with pre-existing blood disorders may be at increased risk; monitor blood counts regularly. Interrupt treatment in patients who develop cytopenia; may restart once cause of cytopenia is determined; contraindicated if platelet count <50,000/mm3.

6. Gastrointestinal events: Gastrointestinal bleeding (including death) may occur; more common in patients with advanced hematological malignancies and/or elderly patients with low platelet counts; discontinue treatment for suspected gastrointestinal bleeding or ulceration. Monitor patients closely for signs/symptoms of gastrointestinal ulceration/bleeding while taking deferasirox.

The above is the relevant content of precautions!