用地拉罗司治疗时需要注意什么呢？

(Deferasirox) is used for patients with iron accumulation due to long-term blood transfusion (such as thalassemia or other rare anemias). It is suitable for children over two years old and adults. Deferasirox (Deferasirox) is an oral active chelating agent that is highly selective for iron (Fe3+). It is a ligand with 3 protrusions that binds iron with high affinity in a 2:1 ratio. So, what should you pay attention to when treating with Deferasirox?

Precautions when taking Deferasirox (Deferasirox): Deferasirox (Deferasirox) may cause rash. Generally, the rash will disappear automatically without the need to adjust the dose or stop the medication; if the situation is serious or persistent, the medication should be stopped. The patient's vision or hearing may be affected. It should be taken 30 minutes before meals. It should be taken at the same time every day. Deferasirox (Deferasirox) should not be taken at the same time as drugs containing aluminum (such as gastric acid neutralizers).

Common adverse reactions of taking Deferasirox: diarrhea, vomiting, headache, abdominal pain, fever, rash, increased serum creatinine, etc. Other adverse reactions: increased liver enzymes, cough, throat inflammation, urticaria. While taking medicine, patients with thalassemia are often physically weak, so they should live cautiously in daily life, adapt to cold temperatures, and pay attention to preventing external infections; engage in more outdoor activities; breathe fresh air; and perform appropriate physical exercises, Qigong exercises, Tai Chi, etc. to enhance physical fitness and disease resistance.

In addition, you need to pay attention to drug interactions when taking Deferasirox:

1. Avoid combination with strong inducers of UDP-glucuronosyltransferase (UGT) (such as rifampicin, phenytoin, sedatives and hypnotics, protease inhibitors) and cholestyramine.

2. It cannot be administered at the same time as aluminum-containing antacids. Not to be combined with other iron chelation treatments.

3. Be careful with repaglinide, drugs with potential ulcerogenic effects such as NSAIDs, cortisones, or oral bisphosphonates, drugs metabolized by CYP3A4 (such as cyclosporine, simvastatin, hormonal contraceptives). Withhold deferasirox at least 5 days before performing gallium-67 imaging.

The above is the content of (Enrig, Deferasirox) precautions, I hope it can help you!