Deferasirox怎么使用？

(Deferasirox, Enrig) plays a good auxiliary role in patients with thalassemia or other rare anemias that require long-term blood transfusions resulting in iron accumulation (people who require long-term blood transfusions (blood transfusion volume up to 100 ml/kg) and serum ferritin exceeds 1000 μg/L). Deferasirox (Deferasirox, Enrig) ​​is very effective. So, how to use Deferasirox (Deferasirox, Enrig)?

Deferasirox dispersible tablets should be taken once daily on an empty stomach, at least 30 minutes before a meal, preferably at the same time each day. Tablets should not be chewed or swallowed whole. Deferasirox (Deferasirox, Enrig) ​​dispersible tablets should not be taken together with aluminum-containing antacids, and the dose (mg/kg) needs to be calculated and rounded to the nearest whole tablet.

Completely dissolve the tablets in water, apple juice or orange juice (100-200 mL) by stirring with Deferasirox (Deferasirox, Enrig) until a clear suspension is obtained and then drink it. The remaining drug must be added to a small amount of water, apple juice or orange juice and mixed well before taking it. Not recommended for dissolution in carbonated drinks or milk as it can cause foaming and slow dispersion.

Deferasirox (Deferasirox, Enrig) Dose Adjustments: Myelosuppression: Interrupt treatment; may restart once cause of cytopenias is determined; Contraindicated if platelet count <50,000/mm; Cutaneous Toxicity: Rash (serious): Interrupt treatment; may reintroduce at lower doses (with future dose escalations) and short-term oral corticosteroids.

Severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme): Discontinue Deferasirox and evaluate. Gastrointestinal: Discontinue treatment for suspected gastrointestinal ulceration or bleeding. Hearing loss or visual impairment: Consider dose reduction or treatment interruption.

Common adverse reactions when taking Deferasirox (Deferasirox, Enrig): diarrhea, vomiting, headache, abdominal pain, fever, rash, increased serum creatinine, etc. Other adverse reactions: increased liver enzymes, cough, throat inflammation, urticaria. While taking medicine, patients with thalassemia are often physically weak, so they should live cautiously in daily life, adapt to cold temperatures, and pay attention to preventing external infections; engage in more outdoor activities; breathe fresh air; and perform appropriate physical exercises, Qigong exercises, Tai Chi, etc. to enhance physical fitness and disease resistance.

The above is the content of how to use (Deferasirox, Enrego), I hope it can help you!