地拉罗司可治疗哪些疾病？

What diseases can (ENRIG) treat? Let's take a look. Deferasirox (Enrige) is an iron chelator product developed by the Swiss pharmaceutical company Novartis. It is the first oral iron anthelmintic approved by the US FDA for routine use.

Indications for Deferasirox (Enrige):

1. Patients with chronic iron overload transfusion hemosiderinosis secondary to blood transfusion who are 2 years old or older will develop symptoms of chronic iron overload when serum ferritin continues to be >1000 L. At this time, iron chelation therapy should be started.

2. Iron chelators can also be given to patients undergoing ASCT when iron overload occurs.

3. It can be used to treat patients with reversible renal insufficiency caused by Fanconi syndrome.

In addition, in Europe, deferasirox (Enrig) is recommended as the first-line drug for patients with thalassemia iron overload over 6 years old, and clinical research is currently underway in China. Phase II and III clinical trials and pharmacokinetic studies have shown that deferasirox has good safety and tolerability, can significantly reduce iron load in the heart and liver, and is easily accepted by patients. At the same time, Deferasirox (Enrige) also has pharmacological properties such as antifungal (such as Mucor that grows in an iron-rich environment), anti-cell proliferation, anti-malarial, anti-oxidative stress damage, anti-cytotoxic-induced apoptosis, etc.; it can be used for the treatment of secondary hemochromatosis, porphyria cutanea tarda and other diseases.

Deferasirox should be taken once daily on an empty stomach, at least 30 minutes before a meal, preferably at the same time each day. Tablets should not be chewed or swallowed whole. (Enrig) ​​should not be taken with antacids containing aluminum. The dosage (mg/kg) needs to be calculated and rounded to the nearest whole tablet. Completely dissolve the tablets in water, apple juice or orange juice (100-200mL) by stirring until a clear suspension is obtained and then drink it. The remaining medicine must be added with a small amount of water, apple juice or orange juice and mixed well before taking. Not recommended for dissolution in carbonated drinks or milk as it can cause foaming and slow dispersion.

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