地拉罗司怎么服用效果最好？

(Enrig) is used to treat chronic iron overload caused by frequent blood transfusions (monthly administration of concentrated red blood cells ≥7 mL/kg) in patients with beta-thalassemia older than 6 years old. For iron overload caused by children under 6 years old and other transfusion-dependent diseases, the safety and effectiveness data of Enrig in Chinese patients are limited. It is recommended to use it with caution based on the specific situation of the patient. So, how to take deferasirox (Enrig) ​​with the best effect?

How to use and dose Deferasirox (Enrig): The recommended starting daily dose of Deferasirox (Enrig) is 20 mg/kg. For patients who receive monthly transfusions of more than 14 mL/kg of packed red blood cells (ie, more than 4 units/month in adults) and who need to reduce excess iron exposure, a starting dose of 30 mg/kg/day may be considered. For patients who receive monthly transfusions of less than 7 mL/kg of packed red blood cells (i.e., less than 2 units/month in adults) and who need to maintain body iron balance, a starting dose of 10 mg/kg/day may be considered. In patients who have already responded well to deferoxamine therapy, an initial dose equivalent to half the deferoxamine dose may be considered. Take it on an empty stomach at least 30 minutes before meals, once a day, preferably at the same time every day.

Deferasirox (Enreg) dose adjustment:

Myelosuppression: Interrupt treatment; may restart once cause of cytopenias is identified; Contraindicated if platelet count <50,000/mm; Cutaneous Toxicity: Rash (severe): Interrupt treatment; may reintroduce at lower doses (with future dose escalation) and short-term oral corticosteroids. Serious skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme): Stop and evaluate. Gastrointestinal: Discontinue treatment for suspected gastrointestinal ulceration or bleeding. Hearing loss or visual impairment: Consider dose reduction or treatment interruption.

The above is the (Enrige) medication guide provided by our medical companion tour. As long as the patient takes the medicine strictly according to the instructions, the effect will be optimal.

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